Piperine, possibly along with its isomer chavicine, [2] is the compound [3] responsible for the pungency of black pepper and long pepper. It has been used in some forms of traditional medicine. [4] Due to its poor solubility in water, piperine is typically extracted from black pepper by using organic solvents like dichloromethane. [5] .

胡椒碱是一种广谱抗 惊厥 药，化学式为C17H19NO3。 无色单斜棱形晶体，无气味，有尝后灼烧感。 对石蕊试剂呈中性。 易溶于氯仿、乙醇、乙醚，溶于苯和乙酸，几乎不溶于水和石油醚 [1]。 可以在为胡椒科植物胡椒（Piper nigrum L. ）的干燥近成熟或成熟果实中提取倒。 对小鼠实验性电惊厥有良好的对抗作用，对 戊四氮 、 印防己毒素 、 士的宁，以及脑室内注射 筒箭毒碱 、 谷氨酸 等引起的惊厥发作和听源性发作，都有不同程度的对抗作用。 对某些类型的癫痫病也有疗效 …

This review highlights and discusses the medicinal and health-promoting effects of piperine, along with possible mechanisms of its action in health promotion and disease prevention. In addition, the present review summarizes the recent literature related to piperine as a therapeutic agent against several diseases.

2021年9月1日 · BioPerine, a piperine extract found in supplements, may help improve nutrient absorption and blood sugar levels, fight cancer and inflammation, and enhance cognitive function. That said, more...

已发现 Piperine 具有免疫调节、抗氧化、抗哮喘、抗癌、抗炎、抗溃疡和抗阿米巴特性 [2]。 Piperine 可通过抑制 CYP3A 和 P-糖蛋白活性来提高瑞舒伐他汀、紫杉醇和多西紫杉醇 (DOX) 等其他药物的生物利用度 [3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 在 3.5 mg/kg 的剂量下，Piperine 的生物利用度为 25.36%。 其 AUC 0→t 随剂量不成比例地增加，表明 Piperine 具有潜在的非线性药代动力学特征。

Piperine is a N-acylpiperidine that is piperidine substituted by a (1E,3E)-1- (1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum. It has a role as a NF-kappaB inhibitor, a plant metabolite, a food component and a human blood serum metabolite.

胡椒鹼 是一種 生物鹼，化学式 C 17 H 19 NO 3，與 胡椒脂鹼 （chavicine，為胡椒鹼之 顺反 異構體）同是 黑胡椒 辣味 的來源主成分 [1]。 它被使用在某些形式的 傳統醫學 及 殺蟲劑 中。 辣椒素 和胡椒鹼所造成的辣味，是藉由打開 痛覺神經 上的 TRPV 離子通道 ──用來感受熱與酸味的 TRPV-1通道 而產生的。 此外，胡椒鹼被發現能夠抑制人體中的 細胞色素P4503A4 （簡稱CYP3A4）及 P-醣蛋白，兩種在 新陳代謝 及 異生質物 、 代謝物 之運輸上有重要地位的 酶 …

Piperine is a plant-derived promising piperamide candidate isolated from the black pepper (Piper nigrum L.). In the last few years, this natural botanical product and its derivatives have aroused much attention for their comprehensive biological ...

Piperine is a type of amide alkaloid that exhibits pleiotropic properties like antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective, neuroprotective and enhancing bioavailability and fertility-related activities.

Piperine (PIP) is an active alkaloid of black and long peppers. An increasing amount of evidence is suggesting that PIP and its metabolite’s could be a potential therapeutic to intervene different disease conditions including chronic inflammation, cardiac and hepatic diseases, neurodegenerative diseases, and cancer.