2025年3月30日 · PHGDH (Phosphoglycerate Dehydrogenase) is a Protein Coding gene. Diseases associated with PHGDH include Phosphoglycerate Dehydrogenase Deficiency and Neu-Laxova Syndrome 1. Among its related pathways are serine and glycine biosynthesis and One-carbon metabolism and related pathways.

2024年7月1日 · In this review, the structural aspects of PHGDH and its involvement in one-carbon metabolism are investigated, and PHGDH is proposed as a potential therapeutic target in diverse cancers.

Phosphoglycerate dehydrogenase deficiency is a condition characterized by an unusually small head size (microcephaly); impaired development of physical reactions, movements, and speech (psychomotor retardation); and recurrent seizures (epilepsy).

2025年2月9日 · phosphoglycerate dehydrogenase (PHGDH), the first committed enzyme in the serine synthesis pathway (SSP), is a critical driver for Sorafenib (and other tyrosine kinase inhibitors ) resistance in hepatocellular carcinoma.

PHGDH is a dehydrogenase whose expression in cancers was first demonstrated in 2010. Because its silencing allows a significant reduction in tumor proliferation, it appears to be a promising target in the development of new anti-cancer agents.

2014年5月1日 · At least eight mutations in the PHGDH gene have been found to cause phosphoglycerate dehydrogenase deficiency. This condition is characterized by an unusually small head size (microcephaly), severe developmental delay, and recurrent seizures that are difficult to treat (intractable epilepsy).

2022年5月18日 · Here we find that the loss of phosphoglycerate dehydrogenase (PHGDH) potentiates metastatic dissemination. Specifically, we find that heterogeneous or low PHGDH expression in primary tumours...

PHGDH functions as the rate-limiting enzyme in serine synthesis, governing 1C metabolism. In 1C metabolism, PHGDH has the capacity to modulate the redox balance, nucleotide synthesis, and epigenetic processes.

2025年2月9日 · Title: Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism, and mTORC1 signaling. PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress.

2 天之前 · PHGDH is upregulated in MDR GC cells, and this phenotype is correlated with poor prognosis. To investigate the mechanisms of MDR in GC, we compared the gene expression profiles of chemosensitive ...