2025年2月12日 · 通过研究 pdz 结构域的结合特性和功能，科学家们可以更好地理解细胞内信号转导的复杂网络，为疾病治疗和药物开发提供新的靶点和思路。 总之，PDZ 蛋白结构域在细胞信号转导中发挥着关键作用，其多样性和复杂性为生命科学研究提供了丰富的研究内容和潜在 ...

The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses [1] and animals. [2] . Proteins containing PDZ domains play a key role in anchoring receptor proteins in the membrane to cytoskeletal components.

与 ptb 和 ph 结构域相似，pdz 结构域也缺少常见肽结合特异性，并且能与肽和脂质相互作用。 目前有 4 类不同的 PDZ 相互作用：识别肽的羧基末端基序、识别肽的内部基序、 PDZ - PDZ 二聚化和识别脂质。

2010年5月28日 · PDZ domains are abundant protein interaction modules that often recognize short amino acid motifs at the C-termini of target proteins. They regulate multiple biological processes such as transport, ion channel signaling, and other signal transduction systems.

Currently, the best recognized classes are class 1 PDZs, which bind c-terminal motifs with the sequence X-S/T-X-Φ-COOH; class 2 PDZs, which have micromolar affinity for the sequence X-Φ-X-Φ-COOH; and class 3 PDZs, for ligands which end with X-D/E X-Φ-COOH. In this scheme, X represents any amino acid residue and Φ any hydrophobic residue.

Once termed Discs-large homology regions (DHRs) or GLGF repeats (after a conserved Gly-Leu-Gly-Phe sequence found within the domain), these domains of ∼90 amino acids are now primarily known by an acronym of the first three PDZ-containing proteins identified: the postsynaptic protein PSD-95/SAP90, theDrosophila septate junction protein Discs ...

2004年10月1日 · PDZ domains are modular protein-interaction domains that are specialized for binding to C-terminal peptide motifs of other proteins. PDZ-domain-based scaffolds typically assemble large...

2019年1月1日 · Post-synaptic density-95, disks-large and zonula occludens-1 (PDZ) domains are small globular protein–protein interaction domains widely conserved from yeast to humans. They are composed of ∼90 amino acids and form a classical two α-helical/six β-strand structure.

utilize peptide ligands of PDZ domains to define their lulose membranes. Eight synthetic steps, in addition to molecular recognition properties and to generate an an- the condensation of the Fmoc-protected amino acids,

The PDZ-LIM protein RIL modulates actin stress fiber turnover and enhances the association of alpha-actinin with F-actin. Exp. Cell Res. 2004;293:117–128. doi: 10.1016/j.yexcr.2003.09.004.