2024年12月25日 · PAK3 (P21 (RAC1) Activated Kinase 3) is a Protein Coding gene. Diseases associated with PAK3 include Intellectual Developmental Disorder, X-Linked 30 and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Signaling by Rho GTPases and Integrin Pathway.

PAK3 (p21-activated kinase 2, beta-PAK) is one of three members of Group I PAK family of evolutionary conserved serine/threonine kinases. [5][6][7] PAK3 is preferentially expressed in neuronal cells [8][9] and involved in synapse formation and …

2024年3月7日 · We showed that interneurons expressing a constitutively kinase active PAK3 variant (PAK3-ca) extended shorter leading processes and exhibited unstable polarity. In the upper cortical layers,...

PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth. The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.

The PAK family consists of six members and divided into two groups, group I (PAK1, PAK2, and PAK3) and group II (PAK4, PAK5, and PAK6). PAK5 is sometimes referred to as PAK7. The PAK gene sequences and their structures are conserved from amoeba, yeast, Caenorhabditis elegans, Xenopus, to human (Kumar et al., 2009).

该基因编码的蛋白质是一种丝氨酸-苏氨酸激酶，与 GTP 结合的 Ras 样 (P21) 、CDC2 和 RAC1 形成活化复合物。 这种蛋白质对于树突发育和与突触可塑性相关的树突棘中的快速细胞骨架重组可能是必需的。 该基因的缺陷是 X 连锁智力障碍的非综合征形式的原因。 已经鉴定出编码不同亚型的选择性剪接转录物变体。 [RefSeq 提供，2017 年 7 月] The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), …

2021年10月25日 · A recent study evaluating 155 AML patient samples found that high PAK3 and PAK5 were associated with poor event-free survival (EFS) and OS .

2021年8月18日 · 研究人员发现， PAK3是Smad4的下游效应因子，其能够通过PAK3-JNK-Jun信号通路介导转移性信号的转导。 Smad4 LOF在SPK小鼠中对PAK3表达水平的上调是通过减弱microRNA miR-495和miR-543的Smad4依赖性转录来实现的。

2022年1月1日 · P21-activated kinase 3 (PAK3) is a serine/threonine protein kinase, and PAK3 affects the EMT, proliferation, metastasis and invasion of HCC. Methods: In this study, the relationship between PAK3 and HCC was first analyzed by bioinformatics, and then, the expression of PAK3 in clinical samples was detected by immunohistochemistry (IHC ...

2024年10月10日 · Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells. PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.