Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene. [5] [6] PAK2 is one of three members of Group I PAK family of serine/threonine kinases. [7] [8] The PAKs are evolutionary conserved. [9] PAK2 and its cleaved fragment localize in both the cytoplasmic or nuclear compartments.

2025年3月30日 · PAK2 (P21 (RAC1) Activated Kinase 2) is a Protein Coding gene. Diseases associated with PAK2 include Knobloch Syndrome 2 and Knobloch Syndrome. Among its related pathways are Signaling by Rho GTPases and Autodegradation of the E3 ubiquitin ligase COP1.

2025年2月1日 · In neuronal cells, PAK2 has been identified as a key regulator of glucose uptake, pyruvate metabolism, and PKM2-associated feedback mechanisms, which highlight PAK2's central role in regulating cancer metabolism and immune evasion, providing a survival mechanism for tumor cells in fluctuating microenvironments [52]. Overall, PAK2 not only ...

This review highlights the biological significance of PAK2 in cancer and its interactions with critical signaling pathways, offering valuable insights for future research. We also discuss the major obstacles in developing PAK inhibitors and propose strategies to overcome these barriers, paving the way for their clinical translation.

2017年6月29日 · pak2 是一类丝氨酸/苏氨酸蛋白激酶，具有高度、严格的序列同源性。 既往研究证实，PAK2 作为一种效应分子，可通过多种不同的途径参与包括调节细胞骨架重构和细胞运动等多种细胞内生物学活动[3-5] 。

PAK（p21激活的激酶）是肌动蛋白动力学、细胞增殖和细胞存活的关键调节剂。 同时PAK还被认为是肌动蛋白细胞骨架和运动的主要调节因子。 由于它们在肌动蛋白重塑中的核心作用及其激活基质金属蛋白酶（MMPs）的能力，…

p21 活化激酶 (PAK) 是将 Rho GTP 酶与细胞骨架重组和核信号转导联系起来的关键效应物。 PAK 蛋白是一个丝氨酸/苏氨酸激酶家族，可作为小 GTP 结合蛋白、CDC42 和 RAC1 的靶标，并涉及广泛的生物活性。 由该基因编码的蛋白质在半胱天冬酶介导的细胞凋亡过程中被蛋白水解切割激活，并可能在调节垂死细胞的细胞凋亡事件中发挥作用。 [RefSeq 提供，2008 年 7 月] The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to Cytoskeleton …

PAK2, a gene frequently amplified in adult T-Cell Leukemia/Lymphoma (ATLL), facilitates CADM1-mediated stromal interaction and promotes survival of ATLL cells. The pan-PAK inhibitor PF-3758309 (PF) has strong in vitro and in vivo activity in a variety of ATLL preclinical models.

2023年2月22日 · We demonstrated that PAK2’s interaction with PLK1 protected it from degradation by APC/C Cdh1, and that it promoted meiotic progression and bipolar spindle formation. Our data collectively...

2014年5月13日 · In this study, we show that T-cell specific deletion of Pak2 gene in mice resulted in severe T cell lymphopenia accompanied by marked defects in development, maturation, and egress of thymocytes. Pak2 was required for pre-TCR β-selection and positive selection.