2025年3月30日 · PAK1 (P21 (RAC1) Activated Kinase 1) is a Protein Coding gene. Diseases associated with PAK1 include Intellectual Developmental Disorder With Macrocephaly, Seizures, And Speech Delay and Neurofibromatosis. Among its related pathways are EPH-Ephrin signaling and Semaphorin interactions.

Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene. [5] [6] PAK1 is one of six members of the PAK family of serine/threonine kinases which are broadly divided into group I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK6 and PAK5/7). [7] [8] The PAKs are evolutionarily conserved. [9]

2025年3月8日 · The activation of Nef-associated kinase (NAK; also known as p21-activated kinase 1 or PAK1) by HIV-1 Nef is via the small GTPases Cdc42 and Rac1, suggesting an interaction between Nef and these GTPases

PAK（p21激活的激酶）是 肌动蛋白动力学 、细胞增殖和细胞存活的关键调节剂。 同时PAK还被认为是肌动蛋白细胞骨架和运动的主要调节因子。 由于它们在肌动蛋白重塑中的核心作用及其激活 基质金属蛋白酶 （MMPs）的能力， Rho GTP酶 在肿瘤细胞侵袭和转移中起重要作用。 目前的证据表明PAKs参与运动、细胞存活、锚定非依赖性生长、血管生成、侵袭，迁移和细胞周期和有丝分裂的调节。 因此，PAK也涉及许多病理状况，包括癌症。 有大量证据表明异常的Rho家 …

2020年8月1日 · Here, we provide an overview of essential roles that PAK1 plays in cancer, including its structure and autoactivation mechanism, its crucial function from onset to progression to metastasis, metabolism, immune escape and even drug resistance in cancer; endogenous regulators; and cancer-related pathways.

PAK1 is known to protect cells from apoptosis through at least three different pathways involving FKHR, Bcl-2 and DLC1. In the regulation of cellular proliferation, PAK1 regulates activity of Raf and Aurora kinases. PAK1 is also known to regulate cellular respiration via phoshorylations of p47- and p67- phox proteins.

p21-activated kinase 1 (PAK1) has attracted much attention as a potential therapeutic target due to its central role in many oncogenic signaling pathways, its frequent dysregulation in cancers and neurological disorders, and its tractability as a target for small-molecule inhibition.

Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; nervous system development; and positive regulation of cell migration.

PAK1 has recently attracted increasing attention owing to its involvement in oncogenesis, tumor progression, and metastasis as well as several life-limiting diseases and pathological conditions. In Caenorhabditis elegans, PAK1 functions limit the lifespan under basal conditions by inhibiting forkhead transcription factor DAF-16.

2023年10月9日 · PAK1 is a specific activator for cytoskeleton remodeling that enables the endocytosis of vaccinia virus, 37 African swine fever virus, 38 and respiratory syncytial virus. 39 We found that PAK1...