2025年3月30日 · PABPC1 (Poly(A) Binding Protein Cytoplasmic 1) is a Protein Coding gene. Diseases associated with PABPC1 include Rift Valley Fever and Dengue Virus. Among its related pathways are Peptide chain elongation and Nervous system development. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.

本文将主要介绍PABPC1的结构、表达调控、功能及其生物学作用. 多聚腺苷酸结合蛋白（poly (A)binding protein,PABP)是一类高度保守的RNA结合蛋白，普遍存在于真核生物中，能够特异性地识别并结合多聚腺苷酸序列. PABP家族按照其在细胞中的定位主要分为两种：细胞核PABP (nuclear poly (A)binding protein，PABPN)和细胞质PABP (cytoplasmic poly (A) binding protein，PABPC). 这些家族成员本身缺乏催化活性，但能够在细胞中结合poly（A）尾巴并与其 …

Mammalian poly A-binding proteins (PABPs) are highly conserved multifunctional RNA-binding proteins primarily involved in the regulation of mRNA translation and stability, of which PABPC1 is considered a central regulator of cytoplasmic mRNA homing ...

Polyadenylate-binding protein 1 is a protein that in humans is encoded by the PABPC1 gene. [5] The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stability.

2025年3月18日 · Our high-throughput CRISPR–Cas9 screening identified poly (A) binding protein cytoplasmic 1 (PABPC1) as a driver for CML progression in the BC stage. PABPC1 preferentially improved the...

2024年6月5日 · PABPC1 是一种核质穿梭蛋白，过往的研究显示其在调控 mRNA 的加工转运、稳定性维持和翻译过程中发挥重要功能。 该研究发现， H9 细胞核中的 PABPC1 能够结合这些 (A)-rich 的环形 RNA，形成的复合物被核篮蛋白 TPR 捕获而被滞留于核中。 此前 TPR 被认为可以参与抑制剪接异常的线性 RNA 出核，从而对线性 RNA 出核进行质控，该研究结果表明 TPR 也在环形 RNA 出核调控中具有重要功能。 有意思的是，在神经分化过程中，细胞核内 PABPC1 的 …

2025年3月16日 · HIV-1 Rev interacting protein, poly (A) binding protein 1 (PABPC1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PABPC1 is increased by RRE. HIV-1 PR-induced PABP cleavage is involved in the inhibition of poly (A)-dependent translation.

2024年6月20日 · In the H9 nucleus, newly produced (A)-rich circRNAs are bound by PABPC1 and trapped by the nuclear basket protein TPR to prevent their export. Modulating (A)-rich motifs in circRNAs alters their subcellular localization, and introducing (A)-rich circRNAs in H9 cytosols results in mRNA translation suppression.

pabpc1 蛋白通过形成生物分子凝聚体，优先提高了多个具有长且高度结构化的 5' 非翻译区（5' utr）的白血病致病 mrna 的翻译效率。

该蛋白质在细胞核和细胞质之间穿梭，并通过 RNA 识别基序与真核信使 RNA 的 3' poly (A) 尾部结合。 该蛋白与 poly (A) 的结合促进核糖体募集和翻译起始；它也是 poly (A) 缩短所必需的，这是 mRNA 衰变的第一步。 该基因属于一个小基因家族，包括三个蛋白质编码基因和几个假基因。 [RefSeq 提供，2010 年 8 月] This gene encodes a poly (A) binding protein.