Comorbid primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) represent a unique disease phenotype with a different risk profile than PSC or IBD alone. While the pathogenetic mechanisms behind both diseases remain unclear, recent studies have targeted several immune-mediated pathways in an attempt to find a potential ...

2023年7月18日 · PSC-IBD shows distinct clinical findings from classical IBD. In addition, a distinct genetic predisposition and unique microbiota composition suggest that PSC-IBD is an independent...

Background: Inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD) may have a high prevalence of rectal sparing, backwash ileitis, and colorectal neoplasia. Aims: To describe the clinical features and outcomes of PSC-IBD and compare these to a group of chronic ulcerative colitis (CUC) patients.

2023年11月6日 · One of the most striking features of PSC is its association with inflammatory bowel disease (IBD), with the majority of patients with PSC being diagnosed with extensive colitis. This review describes the epidemiology of IBD in PSC, its specific phenotype, complications and potential pathophysiological mechanisms connecting the two diseases.

IBD累及肝胆系统是常见肠外表现之一，最常见就是原发性硬化性胆管炎（PSC），这是一种病因不明的慢性进展性胆汁淤积型肝病，以胆管弥漫性炎症和纤维化为特征，最终可能因胆管梗阻和胆道炎症导致肝硬化和肝衰竭。 本文将重点探讨IBD与PSC的“不解之缘”。 1. IBD合并PSC的 流行病 学特征. IBD可以在PSC病程的任何阶段发现，而PSC也可在IBD病程的任何阶段发现。 总体来看，IBD的 诊断 略早于PSC。 （1）IBD患者中PSC的发病率. 约有2.4%~7.5%的IBD患者合 …

2018年3月28日 · IBD co-existing with PSC is genetically and clinically distinct from IBD alone. It is frequently characterized by pancolitis, rectal sparing, and possibly backwash ileitis, as well as a threefold increased risk of colorectal dysplasia. Adults and children with colitis and PSC appear to …

In this referral centre based study, inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD) was characterised by a high prevalence of pancolitis with rectal sparing and backwash ileitis.

Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic disease that is associated with inflammatory bowel disease (IBD) in approximately 70% of cases. Although the pathogenesis is still unknown for both diseases, there is increasing evidence to indicate that they share a common underlying predisposition.

Background: Inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD) may have a high prevalence of rectal sparing, backwash ileitis, and colorectal neoplasia. Aims: To describe the clinical features and outcomes of PSC-IBD and compare these to a group of chronic ulcerative colitis (CUC) patients.

鉴于与 psc-ibd 相关的恶性肿瘤风险很高，识别高危患者并实施适当的监测和监测策略至关重要。 在这篇综述中，我们概述了 PSC-IBD，它体现了肠-肝轴。 EN