The U.S. Food and Drug Administration (FDA)-approved indications and dosages for the use of proton pump inhibitors (PPIs) in adults are provided in this table. You can find information on the generic availability of PPIs by searching the Electronic Orange Book at

2024年5月31日 · Proton pump inhibitors (PPIs) effectively block gastric acid secretion by irreversibly binding to and inhibiting the hydrogen-potassium ATPase pump that resides on the luminal surface of the parietal cell membrane. This topic review will provide an overview of the mechanism of action, pharmacokinetics, administration, and adverse effects of PPIs.

2023年5月1日 · Proton pump inhibitors represent a class of medications used to treat a wide variety of pathologies related to the stomach's acid production. This activity reviews the indications, action, contraindications for proton pump inhibitors as a valuable agent in managing acid-related disorders.

2015年10月29日 · To help you dispense certain complicated drug classes correctly, we have created pediatric and adult dosing charts as well as fact sheets. The fact sheets summarize the indications, treatment guidelines, and adverse reactions and risks of each drug class.

Understanding relative PPI potency in terms of improving pH>4-time increases PPI effectiveness by increasing the omeprazole equivalents administered, the frequency of PPI administration, or both. Omeprazole equivalents can be increased by increasing a PPI’s dose or substitution of a more potent PPI .

2017年10月18日 · Dosing: Active duodenal ulcer: Oral: 20 mg/day for 4-8 weeks. Erosive esophagitis: Oral: 20 mg/day for 4-8 weeks. Maintenance of healing: 20 mg/day for up to 12 months total therapy. Gastric ulcers: Oral: 40 mg/day for 4-8 weeks. Symptomatic GERD: Oral: 20 mg/day for up to 4 weeks.

In 2004, when the original guideline was developed (CG17), doses of proton pump inhibitors (PPIs) were based on the BNF at the time, as in table 1 below. During the update of this guideline (2014), the guideline development group (GDG) has further defined the PPI doses specifically for severe oesophagitis and Helicobacter pylori (H pylori ...

On the basis of current evidence, it is recommended to withhold PPI’s in all cases of AKI stage 3 until the cause of AKI is established.

* Understand the use of H2RAs and PPIs in the treatment of GERD, duodenal ulcer, gastric ulcer, and erosive esophagitis * Know the doses and duration of the PPIs and H2RAs for their prescribed indication * Recommend the optimal administration time for these medications * Understand the role of selected PPIs in reducing the risk of NSAID

2023年4月17日 · Proton pump inhibitors (PPIs) reduce the production of acid by the stomach. They work by irreversibly blocking an enzyme called H+/K+ ATPase which controls acid production. This enzyme is also known as the proton pump and is …