Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19 [5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin [5] of the cell nucleus.

PML is a tumour suppressor protein that typically localizes to and is necessary for the formation of nuclear macromolecular structures called promyelocytic leukaemia nuclear bodies (PML-NBs)....

Many stress pathways modulate NB formation and recent findings have directly implicated PML in oxidative stress response in vivo. PML may also undergo SUMO-dependent ubiquitination/degradation. We highlight recent advances linking PML to partner degradation and other adaptative post-translational modifications in the context of chromatin ...

2018年6月1日 · PML NBs consist of a shell composed of PML proteins surrounding an inner core filed with dozens of unrelated proteins, and devoid of well-characterized nucleic acids (Figure 1 a,b). In the absence of PML, these partner proteins are distributed in the nucleus, some, like SP100, forming individual dots [5, 6].

2011年1月3日 · PML分子C一末端具有核定位信号而定位在核内称之为PML－NBs的结构中， 并且是PML．NBs形成的关键分子。PML－NBs是一种结合在核基质上的斑点状、 动态的、多蛋白亚核结构，伴随细胞周期发生形态、大小和数量上的变化，细胞

2006年11月3日 · PML nuclear bodies (NBs) are nuclear structures that have been implicated in processes such as transcriptional regulation, genome stability, response to viral infection, apoptosis, and tumor suppression.

PML bodies orchestrate post-translational modifications, particularly stress-induced SUMOylation, impacting target protein functions. Serving as hubs in multiple signaling pathways, they influence cellular processes like senescence. Dysregulation of PML expression contributes to diseases, including cancer, highlighting their significance.

2003年12月8日 · PML epitomizes a multiprotein nuclear structure, the PML-nuclear body (PML-NB), whose proper formation and function depends on PML. Studies in knockout (KO) mice and cells unraveled an...

2018年5月1日 · Decades of research have revealed the importance of PML-NBs in diverse cellular pathways, yet the underlying molecular mechanisms and exact functions of PML-NBs remain elusive. In this review, PML protein modifications and the functional relevance of PML-NB and its associated factors in genome maintenance will be discussed.

PML-NBs are dynamic structures that favour the sequestration and release of proteins, mediate their post-translational modifications and promote specific nuclear events in response to various cellular stresses. Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function.