2024年4月24日 · Here we demonstrate that tumour-derived prostaglandin E2 (PGE2) restricts the proliferative expansion and effector differentiation of TCF1+CD8+ T cells within tumours, which promotes cancer...

In this study, we examined the role of PGE (2) on human DC function. Although studies have suggested that PGE (2) specifically plays a role in DC motility and cytokine release profile, the precise receptor usage and signaling pathways involved remain unclear.

2014年11月1日 · Prostaglandin E2 (PGE2), a very potent lipid mediator produced from arachidonic acid (AA) through the action of cyclooxygenase (COX) enzymes, is implicated in the regulation of dendritic cell (DC) functions such as differentiation ability, cytokine-producing capacity, Th-cell polarizing ability, migration and maturation.

2013年3月25日 · There is emerging evidence that PGE2 plays crucial roles in DC and NK cell biology. Several studies have shown that DCs are not only a source of PGE2, but also a target of its...

2024年8月1日 · In this study, we have identified that PGE2 signaling in bone marrow progenitor cells downregulates miR365, resulting in IL-6 production during DC differentiation, and the resulting miR365/IL-6/STAT3 signaling is a key mediator of PGE2-induced dysfunction of DCs.

In vitro maturation of dendritic cells (DCs) for cancer immunotherapy may be accomplished by cytokine cocktails containing prostaglandin E2 (PGE2). More recently, a poly (I:C)-based protocol has been proposed as a potentially superior alternative because of a strong induction of interleukin (IL)-12 s …

2011年11月11日 · Prostaglandin E2 (PGE2) has been reported to play an essential role in DC migration. We reported previously that PGE2 induces matrix metalloproteinase 9 (MMP-9) expression in DCs and that PGE2-induced MMP-9 is required for DC migration in vivo and in vitro.

2008年1月1日 · Prostaglandin E2 (PGE2), present in inflammatory sites, induces DC migration, presumably by enacting a migration-permissive gene expression program. Since regulation of DC migration is highly important for their use in vaccination and therapy, we examined the PGE2-induced changes in the expression of metalloproteinases (MMPs).

Here, we show that exposure of monocyte-derived DC to PGE2 (10 (-5) M) for 72 h significantly increased DC survivin mRNA and protein expression. In contrast, DC, matured with lipopolysaccharide or tumor necrosis factor alpha, did not reveal survivin induction in …

2013年7月1日 · Using selective EP receptor antagonists and agonists, we demonstrate that PGE 2 coordinates control of IL-23 release (a promoter of Th17, an autoimmune associated T cell subset) in a dose-dependent manner by differential use of EP 2 and EP 4 receptors in LPS-activated MoDCs.