PGE1, which has a cAMP signaling pathway similar to that of PGE2 and stimulates cAMP production more effectively than PGE2 [24,25], has the potential to activate the HCN channel as its target. In sensory neurons, the four subtypes of HCN channels, HCN1–HCN4, can be expressed as different homomers in two main respects [ 18 , 19 ].

PGE1 抑制了 AngII 诱导的 MAPK 信号通路的激活，并且这种作用被 Ntn1 敲低减弱。 阻断 MAPK 信号通路挽救了由 Ntn1 敲低引起的心肌细胞表型，表明 MAPK 信号通路可能作为 N

2021年10月1日 · We found that PGE1 ameliorated AngII-induced cardiac hypertrophy both in vivo and in vitro. The RNA sequencing (RNA-seq) and expression pattern analysis results suggest that Netrin-1 (Ntn1) is the specific target gene of PGE1. The protective effect of PGE1 was eliminated after knockdown of Ntn1.

Pretreatment with PGE1 (1 or 2 μg/kg) significantly improved these cardiological deficits, acting via the glycogen synthase kinase 3β (GSK-3β)-mPTP pathway. Unexpectedly, the phosphorylation of Akt at Ser473 decreased in the PGE1 at high dose.

2018年1月8日 · Collectively, we demonstrated the potential protection of PGE1 on insulin resistance in renal tubules via autophagy-dependent FGF21 pathway in preventing the progression of DN.

2018年1月8日 · These results above in vivo demonstrated that PGE1 may ameliorate insulin resistance in renal tubule through autophagy-dependent FGF21 pathway, resulting in relieving the renal pathology of diabetic rats.

We found that PGE1 ameliorated AngII-induced cardiac hypertrophy both in vivo and in vitro. The RNA sequencing (RNA-seq) and expression pattern analysis results suggest that Netrin-1 (Ntn1) is the specific target gene of PGE1. The protective effect of PGE1 was eliminated after knockdown of Ntn1.

2024年7月16日 · Prostaglandin E-1 (PGE-1), a significant type of prostaglandin, is produced by the oxidation of prostaglandins through cyclooxygenase. This unsaturated fatty acid impedes platelet aggregation,...

2019年12月12日 · Our current studies produced the following novel findings: (i) PGE1 helps to protect against H/R-induced impairment of cell viability as well as cytotoxicity, and abnormal apoptosis; (ii) the down-regulation of H/R-induced inflammatory factors (IL-2, IL-6, P-p65, and TNF-α) is associated with the anti-inflammatory effect of PGE1; (iii ...

Our work suggests that the Nrf2/HO-1 molecular pathway may play a crucial role in treating ICH patients with PGE1 and may represent novel molecular targets, resulting in discovering new drugs for ICH treatment.