However, some recent reviews of studies on PCB exposure and risk of cancer provided discrepant findings. Therefore, we re-evaluated the association between exposure to PCBs and risk of melanoma and NHL by a systematic review and meta-analysis. We retrieved 11 independent cohort studies on occupationally exposed workers.

According to the U.S. Environmental Protection Agency (EPA), PCBs cause cancer in animals and are probable human carcinogens. [4] . Moreover, because of their use as a coolant in electric transformers, PCBs still persist in built environments. [5][6] Some PCBs share a structural similarity and toxic mode of action with dioxins. [7] .

2025年3月28日 · The cancer reassessment determined that PCBs are probable human carcinogens, based on the following information: EPA reviewed all of the available literature on the carcinogenicity of PCBs in animals as an important first step in the cancer reassessment, which presented clear evidence that PCBs causes cancer in animals.

PCB exposure induces various adverse health effects in animals and humans. Environmental and occupational exposures to PCBs have been associated with liver, kidney, endocrine, and neurodevelopmental adverse effects. We have collected and reviewed animal and human data cited in the U.S. National Library of Medicine from 2000–2010.

We performed a systematic review and meta-analysis of scientific literature on the relationship between PCB exposure and human cancer. Two cohorts of people highly exposed to PCBs through ingestion of contaminated rice oil and some cohorts of occupationally exposed workers failed to show a definite increase in total cancer mortality and ...

2017年9月1日 · In 2015 IARC upgraded the classification of PCBs to carcinogenic to human. The studies on PCB exposure and risk of cancer provided discrepant evidences. Our results don't support the hypothesis that PCBs cause melanoma and/or NHL.

2021年9月1日 · Polychlorinated biphenyls (PCBs) are a large family of man-made organic, ubiquitous, and persistent contaminants with endocrine-disrupting properties. PCBs have been associated with numerous adverse health effects and were classified as carcinogenic to humans, but their long-term impact on mortality risk in the general population is unknown.

2021年12月21日 · Polychlorinated biphenyls (PCBs) are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals. Not all PCB mixtures caused tumors in experimental animals. Oral exposure to PCBs caused liver tumors in mice and rats.

2017年9月1日 · The IARC Working Group concluded for sufficient evidence of PCB carcinogenicity for melanoma and limited evidence for non-Hodgkin lymphoma (NHL) and breast cancer. However, a recent meta-analysis found no evidence of association between PCB exposure and the risk of malignant melanoma (Boffetta et al., 2016).

2015年12月21日 · The accumulating epidemiological evidence of elevated cancer risk and mortality in individuals exposed to polychlorinated biphenyls (PCBs) led to their recent classification as human carcinogen by the International Agency for Research on Cancer (IARC) (International Agency for Research on Cancer (IARC), 2015).