PARP2 - Wikipedia
Poly [ADP-ribose] polymerase 2 is an enzyme that in humans is encoded by the PARP2 gene. [5][6][7] It is one of the PARP family of enzymes. This gene encodes poly (ADP …
《Science》癌症特刊：PARP抑制剂深度盘点-上海交大医学院图书馆
PARP抑制剂是一种靶向聚ADP核糖聚合酶 (Poly ADP-ribose Polymerase) 的癌症疗法。 它是第一种成功利用合成致死 (Synthetic Lethality) 概念获得批准在临床使用的抗癌药物。 它的原理不 …
PARP2 Gene - GeneCards | PARP2 Protein | PARP2 Antibody
2025年3月30日 · PARP2 (Poly (ADP-Ribose) Polymerase 2) is a Protein Coding gene. Diseases associated with PARP2 include Fallopian Tube Carcinoma and Cockayne Syndrome. Among …
The contribution of PARP1, PARP2 and poly (ADP-ribosyl)ation …
2021年3月1日 · Here, we investigated the effects of PARP1, PARP2 and PARylation on activities of the main BER enzymes (APE1, DNA polymerase β [Polβ] and DNA ligase IIIα [LigIIIα]) in …
PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP …
1999年6月18日 · We propose to call this enzyme poly (ADP-ribose) polymerase 2 (PARP-2). The PARP-2 gene maps to chromosome 14C1 and 14q11.2 in mouse and human, respectively. …
Understanding specific functions of PARP-2: new lessons for …
2016年9月1日 · The emerging network of PARP-2 target proteins has uncovered wide-ranging functions of the molecule in many cellular processes commonly dysregulated in …
PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid 2-related factor 2 ...
2023年5月15日 · PARP2 is a member of the PARP enzyme family. Although, PARP2 plays role in DNA repair, it has regulatory roles in mitochondrial and lipid metabolism, it has pivotal role in …
PARP-1 and PARP-2: New players in tumour development
In the present review, we highlight emerging information about the redundant and specific functions of PARP-1 and PARP-2 in genome surveillance and DNA repair pathways. …
PARP-2, A novel mammalian DNA damage-dependent poly(ADP …
1999年6月18日 · Purified recombinant mouse PARP-2 is a damaged DNA-binding protein in vitro and catalyzes the formation of poly (ADP-ribose) polymers in a DNA-dependent manner. …
PARP Power: A Structural Perspective on PARP1, PARP2, and …
PARP1, PARP2, PARP5A, and PARP5B are capable of synthesising PAR chains [1, 2, 3]. Most other members in the PARP family catalyse the addition of single ADP-ribose units and are …