2023年8月12日 · Central nervous system (CNS)-specific CtsD-deficient mice exhibit a neurodegenerative disease phenotype with accumulation of ceroid lipofuscins, granular …

2020年3月13日 · Synucleinphagy requires the presence of microglial Toll-like receptor 4 (TLR4), which induces transcriptional upregulation of p62/SQSTM1 through the NF-κB signaling …

2024年1月26日 · We first examined whether hu-α-syn colocalized with p62 and lysosomal-associated membrane protein 1 (LAMP1) to investigate the mechanism underlying the delayed …

We show that basic fibroblast growth factor (bFGF), whose expression is up-regulated in mouse brains after SW injury and ICH, acts synergistically with inflammatory cytokines to activate …

2023年5月18日 · Subsequent analysis indicated decreased expression of the NF-κB-regulated autophagy gene, sequestosome 1 (p62), in microglia, which is required for targeting …

2023年11月24日 · Here we show that protein aggregates and autophagy machinery components accumulate in developmental radial glia-like NSCs as they enter quiescence and that …

2023年5月18日 · PCA of p62 (Figure 8i) and p129 (Figure 8j) represent dimensionally reduced projection patterns of biological sex, rotenone exposure, and genotype where the total …

2023年8月12日 · Central nervous system (CNS)-specific CtsD-deficient mice exhibit a neurodegenerative disease phenotype with accumulation of ceroid lipofuscins, granular …

2018年10月4日 · Realtime PCR results demonstrated IRGM also promoted NF-κB downstream cytokines IL-8 and MIP-3α mRNA expression. These data suggested that IRGM could …

p62 is a multidomain signaling scaffold protein that integrates multiple signaling pathways through its functional domains, including PB1, ZZ, TBS, LIR, and KIR. These domains interact with …