Cell cycle regulation: p53-p21-RB signaling - Nature
2022年3月31日 · Following activation of p53, for example by viral infection or induction of DNA damage, p21 expression is upregulated. High levels of p21 then result in RB-E2F complex …
Multiple functions of p21 in cell cycle, apoptosis and ... - PubMed
The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms. Some other …
Multiple functions of p21 in cell cycle, apoptosis and …
2016年6月1日 · The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms. …
p21(WAF1) mediates cell cycle inhibition, relevant to cancer ...
p21 (WAF1/CIP1; CDKN1a) is a universal cell cycle inhibitor directly controlled by p53 and p53-independent pathways. Knowledge of the regulation and function of p21 in normal and cancer …
New roles for p21 and p27 cell-cycle inhibitors: a function for …
Cell division relies on the activation of cyclins, which bind to cyclin-dependent kinases (CDKs) to induce cell-cycle progression towards S phase and later to initiate mitosis. Since uncontrolled …
p21 in cancer: intricate networks and multiple activities - PMC
p21 responds to a variety of stimuli to promote growth-inhibitory activities that depend primarily on its ability to inhibit the kinase activity of cyclin-dependent kinase 2 (CDK2). p21-induced cell …
Review Multiple functions of p21 in cell cycle, apoptosis and ...
2016年6月1日 · In this review, we will focus on the multiple functions of p21 in cell cycle regulation, apoptosis and gene transcription after DNA damage and briefly discuss the …
Cell cycle regulation by the intrinsically disordered proteins, p21 …
Here, we review disorder-mediated cell cycle regulation by two intrinsically disordered proteins, p21 and p27. A structural adaptation mechanism involving a stretchable, dynamic linker helix …
p21: A Two-Faced Genome Guardian: Trends in Molecular Medicine - Cell …
2017年3月6日 · The key positive effects and functions of p21 were found to correlate with cell cycle regulation, DNA repair, modulation of apoptosis, induction of senescence, and p53 …
p21 in cancer: intricate networks and multiple activities
2009年5月14日 · Through its ability to promote cell cycle inhibition, especially in the face of genotoxic insults or microtubule-destabilizing agents, p21 protects cells from apoptosis …
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