2024年4月29日 · Oxetane - cas 503-30-0, synthesis, structure, density, melting point, boiling point

Oxetane, or 1,3-propylene oxide, is a heterocyclic organic compound with the molecular formula C 3H 6O, having a four-membered ring with three carbon atoms and one oxygen atom. The term "an oxetane" or "oxetanes" refer to any organic compound containing the oxetane ring.

Oxetane | C3H6O | CID 10423 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2016年9月15日 · Oxetanes, as strained cyclic ethers, present a fascinating combination of stable motifs for medicinal chemistry and reactive intermediates for further synthesis. These features make them attractive motifs for an ever-increasing range of applications in the chemical sciences.

Oxetanes are an important four-membered cyclic ether principally occupied as an attractive structural motif in diverse medicinally and bioactive molecules. Apart from this, oxetane serves as a powerful IM in advanced synthesis of a wide range of pharmacologically active molecules.

2016年10月12日 · This review takes an overview of the literature for the synthesis of oxetane derivatives, concentrating on advances in the last five years up to the end of 2015.

2023年9月7日 · The oxetane ring is an emergent, underexplored motif in drug discovery that shows attractive properties such as low molecular weight, high polarity, and marked three-dimensionality.

Known as a nonclassical isoster of the carbonyl group, due to its high polarity and great ability to function as an acceptor of hydrogen bond, oxetane seems to be an attractive and underexplored structural motif in medicinal chemistry. Keywords: oxetane, chemical space, nonclassical isosterism, Buchwald–Hartwig reaction, kinases. 1. Introduction.

An oxetane can trigger profound changes in aqueous solubility, lipophilicity, metabolic stability, and conformational preference when replacing commonly employed functionalities such as gem -dimethyl or carbonyl groups. The magnitude of these changes depends on the structural context.

2023年12月5日 · Provide important insights that can drive future discoveries of novel bioactive oxetane-containing small molecules. The compact and versatile oxetane motifs have gained significant attention in drug discovery and medicinal chemistry campaigns.