Ouabain / w ɑː ˈ b ɑː ɪ n / [1] or / ˈ w ɑː b eɪ n, ˈ w æ-/ (from Somali waabaayo, "arrow poison" through French ouabaïo) also known as g-strophanthin, is a plant derived toxic substance that was traditionally used as an arrow poison in eastern Africa for both hunting and warfare.

2005年6月13日 · Ouabain DrugBank Accession Number DB01092 Background. A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase. Type Small Molecule ...

Ouabain is a steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.

Ouabain, the ligand of Na,K-ATPase, is a steroid derivative that, unlike other steroid hormones, binds specifically to an integral plasma membrane protein. Ouabain derivatives have been used for centuries in the treatment of heart disease. Recent studies demonstrate the presence of endogenous ouabain in mammalian tissues (16–18). The ...

In this brief article, we summarize recent reports about endogenous ouabain (EO), a cardiotonic steroid (CTS). This includes analysis of mammalian EO, the discovery of EO isomers, regulation of intracellular signaling by EO, and the roles of EO in ...

Ouabain (OUA) is an exogenous hormone analog with potent Na/K-ATPase inhibitory effects, and consequent induction of depolarization and neuronal excitation. A single intracerebroventricular (ICV) administration of OUA in animals is able to induce manic-like behavior such as hyperlocomotion, increased exploratory activity, and risk-taking ...

Ouabain (G-Strophanthin) is an active compound found in the Strophanthus gratus plant. G-Strophanthin has been used for over a century for its healing properties.

2025年1月7日 · Ouabain, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.

2013年12月30日 · Ouabain binds to and inhibits the transport activity of the Na + /K + /ATPase (i.e., sodium pump). Ouabain is plant derived and belongs to the class of drugs referred to as cardiac glycosides. Similar to other cardiac glycosides, ouabain …

2025年1月7日 · Learn about Ouabaine uses, dosage, side effects, food interactions, and more. Get all the details about Ouabaine from MedicinesFAQ.