Metalloendopeptidase OMA1, mitochondrial is an enzyme that in humans is encoded by the OMA1 gene. [5] [6] OMA1 is a Zn 2+-dependent metalloendopeptidase in the inner membrane of mitochondria. The OMA1 acronym was derived from overlapping proteolytic activity …

在本篇文章中，我们主要从结构、功能、调节和相关疾病4个方面详细介绍了线粒体蛋白酶OMA1。 1. OMA1结构. 2. OMA1功能. 3. OPA1-OMA1调控机制. 4. OMA1与疾病. 1. OMA1结构. Figure 2. The location of MOA1 gene. 人蛋白金属内切酶OMA1由524个氨基酸组成，其中包含了位于1-13的氨基酸的信号肽，分子量大小为60.1 kDa，成熟OMA1蛋白理论上的pI为8.44 [3]。 该蛋白之所以被称为OMA1，是因为它与 m-AAA蛋白酶 具有重叠活性 [4]。 OMA1的人类直系同源基因 …

Mar 30, 2025 · OMA1 (OMA1 Zinc Metallopeptidase) is a Protein Coding gene. Diseases associated with OMA1 include Snail Allergy and Optic Atrophy 11 . Among its related pathways are Cellular responses to stimuli and Programmed Cell Death .

Dec 13, 2020 · OMA1 knockout suppresses colorectal cancer development in AOM/DSS and xenograft mice models of colorectal cancer. OMA1‐OPA1 axis is activated by hypoxia, increasing mitochondrial ROS to stabilize HIF‐1α, thereby promoting glycolysis in colorectal cancer cells.

Dec 9, 2019 · Here, we investigate the effects of modulating neuronal PHB levels on OMA1 stability and OPA1 cleavage. We demonstrate that PHB promotes OMA1 turnover, effectively decreasing the pool of...

Nov 21, 2003 · Here we describe the identification of a novel conserved metallopeptidase that exerts activities overlapping with the m-AAA protease and was therefore termed Oma1. Both peptidases are integral parts of the inner membrane and mediate the proteolytic breakdown of a misfolded derivative of the polytopic inner membrane protein Oxa1.

OMA1 is a mitochondrial protease. Among its substrates are DELE1, a signaling peptide, which can elicit the integrated stress response, as well as the membrane-shaping dynamin-related GTPase OPA1, which can drive mitochondrial outer membrane ...

OMA1是位于线粒体内膜的锌金属蛋白酶，由OMA1基因编码。 它在维持线粒体动态平衡和应激响应方面发挥着核心作用。 当细胞遭遇应激，如膜电位丧失或线粒体损伤时，OMA1就会被激活，它会切割线粒体融合蛋白OPA1的长亚型，抑制线粒体融合并促进裂变。 不仅如此，OMA1还能降解DELE1和PINK1等蛋白，通过调控线粒体自噬和细胞凋亡，影响细胞的最终命运。 比如在细胞凋亡过程中，Bax/Bak蛋白聚集激活OMA1，引发一系列反应，最终触发凋亡。 OMA1的表达与多 …

Nov 2, 2024 · OMA1 is an ATP-independent zinc metalloprotease essential for maintaining mitochondrial homeostasis and plays a vital role in tumorigenesis. Depending on the type...

Feb 19, 2021 · Remodeling of mitochondrial ultrastructure is a process that is critical for organelle physiology and apoptosis. Although the key players in this process—mitochondrial contact site and cristae junction organizing system (MICOS) and Optic Atrophy 1 (OPA1)—have been characterized, the mechanisms behind its regulation remain incompletely defined.