The ob/ob or obese mouse is a mutant mouse that eats excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese. It is an animal model of type II diabetes. Identification of the gene mutated in ob led to the discovery of the hormone leptin, which is important in the control of appetite.

ob是瘦素的编码基因，利用EGE技术将ob基因2、3号外显子敲除制备的B-ob/ob小鼠，具有肥胖症和高血糖症状，是研究高血糖和肥胖症的有力模型。

2016年8月10日 · Ob/ob mouse 是一种突变小鼠，过量进食，导致非常肥胖。 它是一种2型糖尿病模型。 突变基因ob的证明使我们发现了瘦素，其对食欲的控制很重要。 第一只Ob/ob mouse 是在1949年Jackson 实验室做克隆实验时偶然发现的，属于隐形突变。 突变小鼠刚出生时在形态上与那些没受到影响的小鼠没有不同，但是在生长过程中体重增加得很快，是未突变小鼠的三倍。 突变小鼠的胰岛细胞增加扩大，胰岛素水平提高，但任然会发展得高血糖。 突变的ob基因用定点克 …

This strain is used to model phases I and II of diabetes type II and obesity. Obesity is characterized by an increase in the number and size of adipocytes. Although hyperphagia contributes to the obesity, homozygotes gain excess weight and deposit excess fat even when restricted to a diet sufficient for normal weight maintenance in lean mice.

Microbiome 近期发表的一项研究Novel insights into thegenetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin。 通过对这两种小鼠模型进行比对分析，表明二者的代谢表型差异与特定的炎症调性、血清LPS浓度、胆汁酸代谢、短链脂肪酸谱和肠道菌群组成有关。

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This study was aimed at characterization of PDN in leptin-deficient (ob/ob) mice, a model of type 2 diabetes with relatively mild hyperglycemia and obesity. ob/ob mice ( approximately 11 weeks old) clearly developed manifest sciatic motor nerve conduction velocity (MNCV) and hind-limb digital sensory nerve conduction velocity (SNCV) deficits ...

At approximately 4 weeks old, mice which are homozygous for the obese spontaneous mutation (Lepob; or ob/ob) are first identifiable. Homozygous ob/ob mice gain weight quickly, and may approach a weight of 3 times that of control mice. Besides obesity, these mouse models exhibit hyperphagia, a condition of hyperglycemia, similar to diabetes.

2021年3月18日 · Leptin为肥胖基因（ob）编码产物，是脂肪细胞分泌的蛋白质类激素，在调节能量平衡、摄食行为起重要作用。 若ob基因突变，食欲大增，体重剧增，产生严重的肥胖特征，多用于肥胖症的研究。

The obese diabetic mouse (ob/ob) is an excellent model for the study of obesity and diabetes as it has a longer lifespan and less severe clinical symptoms than the diabetic mouse (db/db).