Deregulation of mitochondrial sirtuins and OGG1-2a acts as a
Survival analysis showed that deregulation of said genes was associated with decreased survival of leukemia patients (SIRT3: p < 0.004; SIRT4: p < 0.0009; SIRT5: p < 0.0001; OGG1-2a: p < …
Loss of Mitochondrial Tumor Suppressor Genes Expression Is …
2016年1月19日 · The expression of mitochondrial tumor suppressor genes (SIRT3, SIRT4 and MTUS1), mitochondrial DNA repair gene (OGG1-2a) and a proliferation marker (Ki-67) was …
Small-molecule activation of OGG1 increases oxidative DNA
2022年6月23日 · Here, we describe a small molecule (TH10785) that interacts with the phenylalanine-319 and glycine-42 amino acids of OGG1, increases the enzyme activity 10 …
miR‐200a Modulates the Expression of the DNA Repair Protein OGG1 …
2018年3月25日 · Notably, OGG1-2a, a critical enzyme for 8-OH-dG repair, is a direct target of miR-200a and its expression levels significantly decrease in aged keratinocytes. The 8-OH-dG …
OGG1 8-oxoguanine DNA glycosylase [ (human)] - National …
OGG1-2a, a critical enzyme for 8-OH-dG repair, is a direct target of miR-200a and its expression levels significantly decrease in aged keratinocytes. The level of OGG1 expression was …
An active alternative splicing isoform of human mitochondrial 8 ...
2015年10月1日 · The major mitochondrial OGG1 isoform, OGG1-2a (also named β-OGG1), has also been expressed and purified; however, its activity is unresolved. Recently, we purified …
miR-200a Modulates the Expression of the DNA Repair Protein OGG1 …
2018年3月25日 · ROS overproduction induces both oxidative DNA lesions, such as 8-OH-dG, and miR-200a expression. Here, we show that OGG1-2a, a BER enzyme critical for 8-OH-dG …
Roles of DNA repair enzyme OGG1 in innate immunity and its …
(a) Two functional isoforms of OGG1. The predominant form of OGG1 is 1a, which localizes both to the nucleus and mitochondria. The OGG1 isoform 2a mainly localizes to the mitochondria. …
线粒体OGG1表达降低与线粒体缺陷和肝癌细胞生长延迟有 …
2013年5月14日 · OGG1-2a 在 MtOGG1 水平较低的 SNU423 细胞中过表达，可有效恢复细胞呼吸和细胞生长活动，并降低细胞内 ROS。 总之，我们的结果表明 mtOGG1 在维持线粒体呼吸 …
DNA损伤修复基因8-羟基鸟嘌呤DNA糖苷酶(OGG1)的研究进展
2016年7月2日 · OGG1 具有 DNA 糖基化酶和脱嘌呤 / 脱嘧啶（ a-purinic/apyrimidinic, AP ）裂解酶活性，可特异性识别和切除DNA 双链中因氧化损伤而产生的 8-oxo-Gua ，从而恢复基因组 …