The nuclear receptor 4A1 (NR4A1 for "nuclear receptor subfamily 4 group A member 1") also known as Nur77, TR3, and NGFI-B is a protein that in humans is encoded by the NR4A1 …

nur77 又称为神经生长因子诱导的基因B (nerve growthfactor-induced gene B NGFI-B) 是一种细胞核孤生受体(orphan nuclear receptor) 转录因子蛋白在多种细胞的信号转导细胞周期细胞凋亡 …

孤儿核受体Nur77 作为核受体的一类,参与机体生理和病理状态下的多个过程。 Nur77可以参与细胞分化、凋亡、代谢和炎症等诸多反应,在动脉粥样硬化、骨质疏松、心肌梗死、哮喘、急性肺 …

2021年12月17日 · Nur77 is a nuclear receptor that has been implicated as a regulator of inflammatory disease. The expression of Nur77 increases upon stimulation of immune cells …

Nur77 expression and activation are rapidly induced by various physiological and pathologic stimuli. Once expressed, Nur77 initiates transcriptional activity and modulates expression of its …

2017年1月15日 · Nur77 is an immediate early gene whose expression is rapidly upregulated by TCR signaling in murine T cells and human thymocytes. Nur77-GFP transgenes serve as …

2023年4月11日 · Biochemical screening for proteins that bound LPS identified Nur77, an orphan nuclear receptor that controls the transcription of a number of genes involved in various …

2009年3月27日 · Emerging data suggest that Nur77 influences vascular homeostasis and disease by controlling the physiology of macrophages, smooth muscle cells (SMCs), and vascular …

2021年2月1日 · Nur77 (NGFI-B) is a nuclear receptor that belongs to the Nr4a family of orphan nuclear receptors (Nr4a1). This transcription factor has been implicated in the regulation of …

These latest findings shed light on the novel roles of Nur77 as an exploitable target for new cancer therapeutics. Further work which focuses on a more complete understanding of the …