2022年12月15日 · Myostatin is a human growth factor that prevents excessive muscle growth, and abnormally high levels can cause the loss of muscle mass. Despite the lack of proper data, myostatin has become a hot topic among athletes and bodybuilders, who claim that inhibiting it can boost muscle growth.

2007年2月6日 · The lack of myostatin promotes growth of skeletal muscle, and blockade of its activity has been proposed as a treatment for various muscle-wasting disorders. Here, we have examined two independent mouse lines that harbor mutations in the myostatin gene, constitutive null (Mstn −/−) and compact (Berlin High Line, BEH c/c). We report that ...

Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle (SM), and its crucial involvement in several disorders has made it an important therapeutic target.

2007年2月6日 · The lack of myostatin promotes growth of skeletal muscle, and blockade of its activity has been proposed as a treatment for various muscle-wasting disorders. Here, we have examined two independent mouse lines that harbor mutations in the myostatin gene, constitutive null (Mstn(-/-)) and compact (Ber …

2017年11月30日 · Our data show that in several neuromuscular diseases the myostatin pathway is shut down at mRNA level in muscle biopsies, leading to low levels of circulating and endogenous muscle myostatin...

2025年1月16日 · Myostatin is produced by skeletal muscle and blocks muscle cell growth and differentiation. The study identifies cross-talk between muscle and the reproductive system and raises questions about interventions to increase muscle mass that might affect fertility.

This study sought to determine whether absence of myostatin altered left ventricular function post-MI. Methods: Myostatin-null mice (Mstn -/- ) and wild-type (WT) mice underwent ligation of the left anterior descending artery to induce MI.

2022年9月24日 · The only known way to block myostatin is through medical interventions like gene therapy and myostatin inhibitor drugs. However, you can reduce myostatin production through exercise. High-intensity resistance training – …

2015年8月25日 · Myostatin, earlier known as growth and differentiation factor 8 (GDF-8), is a member of the TGF-β superfamily. Myostatin has a tremendous impact on the growth and development of skeletal muscle, such that genetic deletions or mutations in the myostatin gene cause a dramatic increase in skeletal muscle mass.

Loss of myostatin has been shown to cause increase in skeletal muscle size and improve skeletal muscle function and fibrosis in the dystrophin-deficient mdx mouse, an animal model for Duchenne muscular dystrophy. We evaluated whether lack of myostatin has an impact on cardiac muscle growth and fibrosis in vivo.