NAPQI, also known as NAPBQI or N-acetyl-p-benzoquinone imine, is a toxic byproduct produced during the xenobiotic metabolism of the analgesic paracetamol (acetaminophen). [1] It is …

The principal toxic metabolite of acetaminophen, N-acetyl-p-benzoquinone imine (NAPQI), is produced by the hepatic cytochrome P-450 enzyme system; glutathione stores in the liver …

N-Acetyl-p-benzoquinone imine (NAPQI), a reactive metabolite of acetaminophen, rapidly reacts at physiological pH with glutathione (GSH) forming an acetaminophen-glutathione conjugate …

Inhibition of glutathione synthetase (GS) by N-acetyl-p-benzoquinone imine (NAPQI) could contribute to 5-oxoprolinuric acidosis in such patients. We investigated the interaction of …

Acetaminophen is the leading cause of acute hepatic failure in many developed nations. Acetaminophen hepatotoxicity is mediated by the reactive metabolite N-acetyl-p …

Overdose will lead to excess NAPQI, which depletes glutathione supply, and reactive intermediates damage hepatocytes. N-acetylcysteine (NAC, Mucomyst®) works by repleting …

Severe liver toxicity (peak AST or ALT >1000 IU/L) develops in virtually all patients who ingest doses in excess of 350 mg/kg. Normal metabolism: supratherapeutic doses (>4g) lead to …

2017年5月4日 · Acetaminophen (Tylenol) is typically metabolized into nontoxic products by means of sulfation and glucoronidation (blue and green paths, respectively). A small …

N-acetyl-p-benzoquinone imine (NAPQI) has been proposed as the toxic metabolite of acetaminophen for the past 10 years, although it has never been detected as an enzymatic …

The breakdown product, N-acetyl-p-benzo-quinone imine; NAPQI) reacts with the sulphydryl groups of glutathione, which are used up by the excessive amount of breakdown product. …