Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a protein that in humans is encoded by the NOD2 gene located on chromosome 16.

今天我们要讲的主角是炎性肠道疾病及其易感基因NOD2。 NOD2基因简介. NOD2 （Nucleotide-binding oligomerization domain 2）也被称为NLRC2，属于NLR家族，是革兰氏阳性和革兰氏阴性细菌的肽聚糖（PGN）衍生的细胞内 模式识别受体 （PRRs）。

Jul 13, 2011 · Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular sensor for small peptides derived from the bacterial cell wall component, peptidoglycan.

The NOD2 gene (previously known as CARD15) provides instructions for making a protein that plays an important role in immune system function. The NOD2 protein is active in some types of immune system cells (including monocytes, macrophages, and dendritic cells), which help protect the body against foreign invaders such as bacteria and viruses.

The nucleotide-binding oligomerization domain (NOD) proteins, NOD1 and NOD2, the founding members of the intracellular NOD-like receptor family, sense conserved motifs in bacterial peptidoglycan and induce pro-inflammatory and anti-microbial ...

nod2是一种胞内受体(图1)，可以识别分子胞壁二肽(mdp)——细菌细胞壁中普遍存在的成分。 细胞中NOD2的激活导致了称为细胞因子的炎症分子的表达，而异常强烈的炎症反应可以介导克罗恩病的肠道损伤。

The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory ...

Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan (PGN)-conserved motifs in cytosol and stimulates host immune response. The association of NOD2 mutations with a ...

Apr 27, 2021 · nod2基因的遗传变异，称为多态性，是克罗恩病相关的最强烈的遗传风险;大约20%的患病风险与该基因的三种单核苷酸多态性有关。此外，nod2突变是回肠狭窄发展和克罗恩病手术需要的强大预测因素，这是这种情况的遗传基础和该疾病的表现之间被广泛证实的联系。

Mar 30, 2025 · NOD2 (Nucleotide Binding Oligomerization Domain Containing 2) is a Protein Coding gene. Diseases associated with NOD2 include Blau Syndrome and Inflammatory Bowel Disease 1. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and SARS-CoV-2 Infection.