新兴靶点NKp46，推动新一代癌症免疫疗法 - 知乎
NKp46（NCR1，CD335）是人类NK细胞的主要激活受体，一种46kDa的糖蛋白，由两个C2型的胞外Ig样结构域组成，属于免疫球蛋白（Ig）超家族。 NKp46主要在静止和激活的NK细胞 …
NKp46 enhances type 1 innate lymphoid cell proliferation and
2025年1月24日 · NKp46 is a critical regulator of natural killer (NK) cell immunity, but its function in non-NK innate immune cells remains unclear. Here, we show that NKp46 is indispensable for …
Multifunctional Natural Killer Cell Engagers Targeting NKp46 …
We report here the generation of trifunctional natural killer (NK) cell engagers (NKCEs), targeting two activating receptors, NKp46 and CD16, on NK cells and a tumor antigen on cancer cells. …
The NK cell receptor NKp46 recognizes ecto-calreticulin on ER
2023年4月5日 · NKp46 recognition of the P domain of ecto-CRT triggers NK cell signalling and NKp46 caps with ecto-CRT in NK immune synapses. NKp46-mediated killing is inhibited by …
Advancements in the Study of the Immune Molecule NKp46 in
2024年11月29日 · NKp46 is a natural killer cell activating receptor primarily expressed on NK cells and non-NK innate lymphoid cells. In the context of anti-infection, NKp46 activates NK …
自然细胞毒性受体 - 百度百科
自然细胞毒性受体（ncr）包括nkp46、nkp30 和nkp44，三者均为 免疫球蛋白超家族 （igsf）成员，但彼此无 同源性 。ncr 只表达于nk细胞表面，是nk 细胞特有的标志，通常在kir/klr 丧失识 …
The NK Cell Receptor NKp46 Acts As an Essential Regulator of …
2023年11月2日 · The NKp46 receptor, encoded by the Ncr1 gene, plays an important role in NK cells. Non-NK immune cells, including ILC1s also express NKp46. However, the role of NKp46 …
NKp46 is the major triggering receptor involved in the natural ...
NKp46 is a novel triggering receptor expressed by all human NK cells that is involved in natural cytotoxicity. In this study we show that the surface density of NKp46 may vary in different NK …
【免疫新思路】—— 首款NKp46三抗在华临床实验获批 - 知乎
NKp46 (NCR1，CD335)是由两个C2型胞外Ig样结构域组成的46kDa糖蛋白，与NKp30和NKp44同属自然细胞毒性受体 (NCR)，是 免疫球蛋白 (Ig) 超家族成员。 NKp46特异表达于静止和激活 …
NKp46 and NKG2D receptor expression in NK cells with CD56dim …
Two of these triggering receptors, the NKp46 natural cytotoxicity receptor (NKp46) and the major histocompatibility complex (MHC) class I-interactive NKG2D receptor, are deficiently …