2025年3月30日 · NFKB1 (Nuclear Factor Kappa B Subunit 1) is a Protein Coding gene. Diseases associated with NFKB1 include Immunodeficiency, Common Variable, 12, With Autoimmunity …

Gene ID: 4790, updated on 8-Feb-2025. This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD …

2025年2月8日 · Gene target information for NFKB1 - nuclear factor kappa B subunit 1 (human). Find diseases associated with this biological target and compounds tested against it in …

The importance of Nfkb1 function can be seen in mouse models, where Nfkb1 (-/-) mice display increased inflammation and susceptibility to certain forms of DNA damage, leading to cancer, …

Nfkb1 and Nfkb2 proteins p105 and p100 serve both as NF-κB precursors and inhibitors of NF-κB dimers. In a biochemical characterization of endogenous cytoplasmic and purified recombinant …

We show that heterozygous loss-of-function variants in NFKB1 are the most common known monogenic cause of CVID, which results in a temporally progressive defect in the formation of …

NFKB1, a core transcription factor critical in various biological process (BP), is increasingly studied for its role in tumors. This research combines literature reviews, meta-analyses, and …

NFKB1 or NFKB2 (164012) is bound to REL (164910), RELA (164014), or RELB (604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, 164008 or …

We present a comprehensive clinical overview of the NF-κB1–related phenotype, which includes immunodeficiency, autoimmunity, autoinflammation, and cancer. Because of its multisystem …

2018年2月23日 · This study has revealed that mutations in the NFKB1 gene are the most common monogenic cause of CVID. The authors highlight that if an NFKB1 mutation is …