2024年4月5日 · NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a...

Inactivation of the Nedd8 conjugation pathway by a dominant negative mutant of the Nedd8-conjugating enzyme Nce1/Ubc12 blocks the ubiquitination and degradation of p27 in cell extracts. Consistent with a role in cell-cycle progression, Nedd8 is expressed in proliferating cells and is itself down-regulated upon cellular differentiation.

Here, we review the NEDD8 pathway, its importance in cancer, and the therapeutic potential of NAE inhibition. Keywords: NEDD8, ubiquitin, cullin-RING ligase, DNA rereplication.

2021年10月12日 · Here, the authors identify similarities and differences of ubiquitin and NEDD8 phosphorylation, showing that phosphorylated NEDD8 has a distinct interactome and regulates HSP70 proteins.

NEDD8 is a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin RING ligases. Many non-cullin neddylation targets have been proposed in recent years. However, overexpression of exogenous NEDD8 can trigger NEDD8 ...

2025年3月30日 · NEDD8 (NEDD8 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with NEDD8 include Malignant Astrocytoma and Parkinson's Disease . Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis .

NEDD8 /RUB1 (NEDD8) is an 8 kDa protein that is closely related to ubiquitin. Just like ubiquitin, NEDD8 can be conjugated to proteins (neddylation). Unlike ubiquitin, however, NEDD8 does not form chains and does not target proteins for degradation [11].

2024年4月27日 · We reveal that NEDD8 loss in cancer cells causes a vulnerability to nivolumab (anti-PD-1). Genetic deletion of NEDD8 only delays cell division initially but cell proliferation is unaffected...

2019年4月3日 · Neddylation is a process of conjugating NEDD8, an ubiquitin-like molecule, to targeted protein substrates via enzymatic cascades involving NEDD8-activating enzyme E1, NEDD8-conjuagating enzyme E2 and substrate-specific NEDD8-E3 ligases.

Here, we review the NEDD8 pathway, its importance in cancer, and the therapeutic potential of NAE inhibition. Keywords: DNA rereplication; NEDD8; cullin-RING ligase; ubiquitin. Cancer cells depend on signals that promote cell cycle progression and prevent programmed cell death that would otherwise result from cumulative, aberrant stress.