Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle (SM), and its crucial involvement in several disorders has made it an important therapeutic target.

2011年11月22日 · The role of Wnt signaling in myoblast differentiation is supported by the fact that myostatin (Mstn), a member of the transforming growth factor-β (TGF-β) superfamily, negatively regulates muscle mass via non-canonical Wnt signaling pathways . Mstn is an important regulator of skeletal muscle development and adult homeostasis.

2009年6月11日 · Together, these data suggest an existence of a genetic interaction between Wnt/β-catenin and Mstn in myofibrillogenesis possibly existing as a negative feedback loop. We propose a model describing regulation of fast muscle fiber growth and maintenance during secondary myofibrillogenesis with respect to Mstn and Wnt signaling .

2021年2月1日 · Myostatin (MSTN) is a negative regulator of muscle growth, and its absence will trigger a positive response to bone. In this study, we examined the effects of LIPUS on bone micro-structure, mechanical properties and damage healing of hindlimb-suspended rats, and investigated whether the inhibition of MSTN plays a role in this process.

This evidence points to a role for Wnt/calcium signaling in the growth and maintenance of postnatal skeletal muscle. This study offers new insight into potential downstream targets of myostatin, which will be beneficial for elucidation of the mechanism through which myostatin acts to inhibit muscle growth.

肌肉生长抑制素（Myostatin，MSTN）是一种肌细胞分泌的肌肉生长负调节因子，前期利用单一脂肪间充质干细胞的研究表明MSTN可以影响肌内脂肪形成，但在既有肌细胞又有前脂肪细胞的情况下MSTN如何发挥作用并不清楚。

Myostatin expression resulted in changes in Wnt pathway signaling. Microarray analysis revealed that a number of genes that encode Wnt pathway components were differen-tially expressed between Mstn / / and Mstn mice (Fig. 2).

目的:探讨肌肉生长抑制素(myostatin,Mstn)基因敲除对2型糖尿病(type 2 diabetic mellitus,T2DM)小鼠骨代谢及骨微结构的影响及机制.方法:将12只野生型(wild-type,WT)、12只杂合型Mstn基因 …

2014年5月28日 · MSTN的最显著作用是作为骨骼肌的强有力的负调控因子，可通过自分泌或旁分泌的方式激活 TGF-β、p38 MAPK、ERK1/2、和 JNK 等信号途径及抑制IGF-AKT和Wnt信号途径，协同抑制成肌细胞的增殖和分化。 MSTN基因敲除小鼠的肌肉重量显著增加而表现为双肌性状，并可通... 肌肉生长抑制素（myostatin，MSTN）又称生长分化因子8（growth differentiation factor 8，GDF-8），属于转化生长因子β（transforming growth factor β，TGF-β）超家族成 …

2022年6月22日 · Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle (SM), and its crucial involvement in several disorders has …