Mice with the head tilt (het) mutation are characterized by impaired otoconial morphogenesis with normal functionality of the auditory system. Here we present an allelic series of mutations at the het locus (including three novel, mutagenesis-induced alleles), affecting the gene for NADPH oxidase 3 ( Nox3 ).

2019年3月1日 · Immunodeficient mice in multiple holding rooms presented with head tilt, circling, spinning when picked up by the tail, dehydration, and lethargy. Burkholderia gladioli, a plant pathogen, was identified as the causative agent.

Head tilt (het) is a recessive mutation in mice causing vestibular dysfunction. Homozygotes display abnormal responses to position change and linear acceleration and cannot swim. However, they are not deaf. het was mapped to the proximal region of ...

Unlike other mouse mutations affecting the vestibular system (such as pallid, mocha and tilted head), the defect in the tilted mouse is highly penetrant, results in the nearly complete absence of otoconia, exhibits no degeneration of the sensory epithelium and has no apparent abnormal phenotype in other organ systems.

Head tilt (het) is a recessive mutation in mice causing vestibular dysfunction. Homozygotes display abnormal responses to position change and linear acceleration and cannot swim. However, they are not deaf. het was mapped to the proximal region of mouse chromosome 17, near the T locus. Here we repor …

1998年11月1日 · Head tilt (het) is a recessive mutation in mice causing vestibular dysfunction. Homozygotes display abnormal responses to position change and linear acceleration and cannot swim. However, they...

Mouse appears to be at score 0.0, but there are obvious signs of head tilting when the walk is observed. The balance is poor. Limp tail and dragging of hind legs. Both hind legs have some movement, but both are dragging at the feet (mouse trips on hind feet). No movement in one leg/completely dragging one leg, but movement in the other leg.

2020年6月8日 · We combined head and eye tracking in freely moving mice and found both observations are explained by two eye-head coupling types, associated with vestibular mechanisms. The first type comprised non-conjugate eye movements, which compensate for head tilt changes to maintain a similar visual field relative to the horizontal ground plane.

Immunodeficient mice in multiple holding rooms presented with head tilt, circling, spinning when picked up by the tail, dehydration, and lethargy. Burkholderia gladioli, a plant pathogen, was identified as the causative agent.

2001年2月1日 · A significant proportion (∼50%) of Pds –/– mice display various signs of vestibular dysfunction, including habitual circling behaviour (A–C), head-tilting (D and E) and head-bobbing, and/or...