2022年1月15日 · In this review, we demonstrate the progress of MOF biofunctionalization with nucleic acid- (ssDNA, ds DNA, and aptamer) and amino acid-based biomolecules (single amino acid, peptide, and protein) for various structure- and function-specific applications.

2018年4月3日 · Here, we design a series of four isoreticular metal-organic frameworks (Ni-IRMOF-74-II to -V) with progressively tuned pore size from 2.2 to 4.2 nm to precisely include single-stranded DNA...

2019年1月23日 · Based upon the observation that clustered oligonucleotides can naturally engage scavenger receptors that facilitate cellular transfection, nucleic acid–metal organic framework nanoparticle (MOF NP) conjugates have been designed and synthesized from NU-1000 and PCN-222/MOF-545, respectively, and phosphate-terminated oligonucleotides.

使用 TFO 探针结合荧光MOF生物传感器检测ds-DNA(来源：ACS Appl. Bio Mater.)。 Wei及其同事设计了一种基于H2dtoaCu-MOF的荧光生物传感器，用于检测H5N1抗体。使用5'6-FAM标记的寡核苷酸作为荧光DNA探针 (P-DNA)。 MOF颗粒吸附 P-DNA，导致染料的荧光强度猝灭。

2020年5月19日 · Here, we show that metal–organic framework nanoparticles (MOF NPs) densely functionalized with oligonucleotides can be programmed to crystallize into a diverse set of superlattices with...

2019年9月15日 · Iron-based MIL-88B MOF nanorods (Tian et al., 2015) have been used as a high-efficient sensing platform for fluorescence DNA detection, with LOD up to 10 pM, and the single point mutation discrimination. In addition, this biosensor is cheap, easy, rapid, and takes only 4 min for the whole "mix-and-detect" process.

近日，江苏大学张祯教授团队在Analytical Chemistry杂志上发表了题为“Insight into the Sensing Behavior of DNA Probes Based on MOF–Nucleic Acid Interaction for Bioanalysis”的研究论文。 此研究通过将类血红素配体FeTCPP集成到常用MOF (UiO-66)中，合成了兼具荧光猝灭能力和过氧化物酶活性的多功能MOF，FeTCPP⊂UiO-66。 以此作为模型探究不同结构DNA探针的荧光及比色传感行为。 结果表明，吸附在FeTCPP⊂UiO-66上的荧光标记DNA通过光致电子转移、荧光共振 …

MOFs中的有机配体通常含有共轭π-电子系统，允许通过π-π相互作用与单链DNA（ssDNA）结合，这种机制类似于氧化石墨烯（GO）和生物分子之间的相互作用 [8]。 如今，MOFs已被广泛应用于化工、医药等各个领域，其中包括均相催化、气体储存与分离、作为药物递送载体、生物成像等。 功能核酸（Functional nucleic acids，FNA）分为天然和人工合成两种，其中，天然FNA包括核酶、核糖开关等，人工合成FNA包括脱氧核酶、核酶、适配体及G-四链体等 [9]。 FNA除了具 …

2025年2月28日 · When ATP-sensitive DNA-modified MOF systems come into contact with ATP-enriched culture medium, ATP interacts with the ATP-sensitive DNA, leading to the unlocking of the MOFs and the release of therapeutic agents. For example, Chen et al. synthesized nanoparticles composed of nucleic acid-binding chain …

19 小时之前 · The possibility of imaging in porphyrin-based MOF leads to real-time monitoring of treatment results and personalization of treatment strategies. ... breast cancer , and lymphoblastic leukemia through control of replication and DNA is called doxorubicin hydrochloride (DOX). Research shows that the delivery of this drug is controlled through ...