3 天之前 · MIST easily and accurately resolves cell function and antigen specificity by vectorizing and integrating transcriptome and TCR data of T cells. In addition, using MIST, we identified the heterogeneity of CXCL13 + subsets in lung cancer infiltrating CD8 + T cells and their association with immunotherapy, providing additional insights into the ...

2 天之前 · MIST 用于转录组和 TCR 整合：MIST 可分别计算来自 GEX、TCR 和联合潜在空间的表示，用于 T 细胞功能表征。 它能同时处理多个单细胞转录组和 TCR 数据集，并自动消除批次效应。 通过对 10x Genomics 的数据集分析发现，MIST 能有效重建 GEX 和 TCR 数据，且随着训练周期增加，重建的准确性提高。 单细胞 GEX 分析：将 MIST 应用于 10x_200k 数据集，其 GEX 编码器有效去除了 scRNA-seq 的批次效应，通过主成分分析、降维可视化和细胞聚类，将细胞分 …

MIST deep learning framework facilitates versatile integrative analysis of T cell transcriptome and TCR. INTRODUCTION. T cell function is greatly influenced by its T cell receptor (TCR), which recognizes antigen and conducts signals for downstream biological processes in a TCR sequence–dependent manner (1, 2).With the advancement of single-cell sequencing, transcriptome and TCR delineation ...

Joint analysis of transcriptomic and T cell receptor (TCR) features at single-cell resolution provides a powerful approach for in-depth T cell immune function research. Here, we introduce a deep learning framework for single–T cell transcriptome and receptor analysis, MIST (Multi-insight for T cell). MIST features three latent spaces: gene expression, TCR, and a joint latent space.

结论：mist通过三层嵌入结构精准解析t细胞功能状态、克隆扩增模式及抗原特异性，并在肿瘤免疫研究中取得重要发现，如揭示cxcl13+cd8+ t细胞在免疫治疗应答中的关键作用，为免疫学研究提供了高效、灵活且可解释性强的工具。

Mi-T-Mist is a topical antimicrobial designed to cleanse the mouthpiece and provide a refreshing agent that will remove residue build-up from the instrument. Easy to use: spray the fine mist on the mouthpeice then let evaporate (about 45 seconds).

Mi-T-Mist is a topical designed to cleanse the mouthpiece and provide a refreshing agent that will remove residue build-up from the instrument. Easy to use: apply the fine mist spray to mouthpiece and let evaporate (about 45 seconds). To freshen and clean the inside of the instrument, spray liberally into the instrument and immediately swab

2016年9月16日 · What is the most popular song on M I S To The T - EP by MIST? When did MIST release M I S To The T - EP?

Often imitated but never replicated, Roche-Thomas’s Mi-T Mist is a topical antimicrobial spray that can be used to disinfect your mouthpiece and remove buildup from the inside of your instrument. Its fine mist sprayer ensures even application and evaporates in roughly 45 seconds.

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