2022年5月2日 · In this study, we found that DA neurons in the mouse ventral tegmental area bidirectionally regulate the activity of 5-HT neurons in the dorsal raphe nucleus (DRN), with weaker stimulation...

2022年7月21日 · Here, we found that glutamatergic projections from the lateral habenula (LHb) to the DRN were activated in male mice that experienced pre-exposure to a rival male mouse (“social instigation”)...

5 天之前 · Excitatory monosynaptic LHb inputs to DRN trigger frequency-dependent indirect inhibition. We used a SERT-Cre::tdTom mouse line to conduct whole-cell electrophysiological recordings from ...

2022年8月17日 · To reveal the underlying patterns of neural activity, we visualized serotonergic neurons in the dorsal raphe nucleus (DRN 5-HT) of mice using miniaturized microscopy during diverse emotional behaviors.

2024年6月28日 · In the present study, we determined the specific impact of NA dysfunction on the physiology of DRN 5-HT and DRN DA neurons by pre-treating a group of mice with desipramine (DMI), a selective inhibitor of NA reuptake, before injecting 6-OHDA (DMI + 6-OHDA mice), which partially prevents striatal NA loss (Figure 3—figure supplement 1E).

2021年2月8日 · Emerging reports using mouse models have demonstrated that DRN DA neurons encode incentive salience and function in both incentive memory expression and sleep regulation. DRN DA neurons and their upstream inputs also contribute to the neural substrate of …

2023年8月23日 · Here using a mouse model, we report a pathway from vesicular glutamate transporter 3 neurons in the dorsal raphe nucleus to dopamine neurons in the ventral tegmental area (VGluT3 DRN →DA VTA) wherein population-level activity in response to innocuous mechanical stimuli and sucrose consumption is inhibited by chronic neuropathic pain.

2023年12月1日 · This study aims to use ultrasound to noninvasively modulate the brain 5-HT levels of mice to promote recovery from GA and improve cognition in mice. The dorsal raphe nucleus (DRN) of mice during GA was stimulated by the 1.1 MHz ultrasound with a negative pressure of 356 kPa, and the liquid chromatography coupled tandem mass spectrometry (LC …

The dorsal raphe nucleus (DRN) is an important source of neuromodulators and has been implicated in a wide variety of behavioral and neurological disorders. The DRN is subdivided into distinct anatomical subregions comprised of multiple cell types, ...

2017年7月27日 · We crossed Vgat-IRES-Cre or VGLUT3-IRES-Cre mice to Cre-dependent GFPL10 reporter mice, which enabled the selective labeling of DRN Vgat or DRN VGLUT3 neurons, respectively. We then evaluated Fos expression in three groups: mice fed ad libitum (fed), mice fasted overnight (fasted), or mice re-fed for 2 hr after an overnight fast (refed).