2016年2月24日 · From wikipedia: "Memantine is a low-affinity voltage-dependent uncompetitive antagonist at glutamatergic NMDA receptors. By binding to the NMDA receptor with a higher affinity than Mg2+ ions, memantine is able to inhibit the prolonged influx of Ca2+ ions, particularly from extrasynaptic receptors, which forms the basis of neuronal excitotoxicity.

2020年5月20日 · Main reasons I started memantine again were for the anti-anhedonia effects and for general focus/motivation and wellbeing. Prior to starting memantine I was struggling with motivation and energy, and have for years. Have trialed the substance before for approx 1 month. First 2 weeks were incredible.

Memantine is great. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. Then memantine is pulled into the channel to its binding site.

“Memantine was started at 5 or 10 mg QHS, before being increased by 5 or 10mg every 4-7 days, as tolerated, to a maximum dose of 40 mg - 60 mg, as tolerated. In all, 13 patients showed complete remission from CRPS with VAS 0 and the disappearance of allodynea for at least nine months after the use of memantine.

Memantine isn't very long term memory impairing, in comparison to DXM, or even Ketamine, but short term memory does seem to suffer a bit and you can lose trains of thought quite easily at high doses. It's clean feeling, compared to DXM.

Memantine is a dissociative, particularly during the startup phase, so it's not surprising that you would feel distanced from anxiety and depression. That doesn't make it a good treatment, though, as there's a massive difference between masking an underlying disorder and actually treating it …

2021年11月22日 · Memantine is quite useful, it helps to stabilize mood in general. As I mentionned though, it seems to work better for impulsivity, anger and irritation. Moclobemide is the holy grail for social anxiety, among those who respond well to it.

2016年3月25日 · Honestly, I think it's because Memantine + nicotine is a bad combo, especially for those (like me) who are addicted to the habituating effects of cigarettes. Memantine is a nAchr antagonist, which feels..unpleasant, if you smoke regularly. This is only my theory.

Looking for more Memantine information regarding Nootropic properties as well as first hand reports. Checked through this sub as well as other places and found information to be lacking. I'm hoping people can share their experiences (as well as what else is in their stack). Also looking for commentary about Memantine's role as a Nootropic.

2017年8月18日 · "The main finding of this study therefore, is that mice trained-on memantine to one platform location are later impaired in spatial learning when trained-off memantine, introducing the possibility that spatial learning for platform locations acquired when training-on memantine inhibited learning in subsequent trainingoff the drug.