Antithrombotic therapy for mechanical heart valves - UpToDate
2023年7月14日 · Surgical replacement of a diseased heart valve with a prosthetic valve aims to improve symptoms and prolong life but also exposes the patient to potential prosthesis-related complications. The frequency of serious complications depends on the valve type, position, and other clinical risk factors.
2020 ACC/AHA Heart Valve Disease Guideline: Key Perspectives…
2020年12月17日 · Mechanical valves: Anticoagulation with vitamin K antagonists (VKAs) is recommended to achieve varying international normalized ratios (INRs) dependent on valve characteristics and patient risk factors (all Class 1).
Circulation
Patients with VHD and AF should be evaluated for risk of thromboembolic events and to treat them with oral anticoagulation if they are at high risk. VKAs are the anticoagulation drugs of choice for patients with rheumatic MS and mechanical heart valves.
Warfarin INR Targets - GlobalRPH
2017年10月3日 · For patients with a bileaflet mechanical valve or a Medtronic Hall (Minneapolis, MN) tilting disk valve in the aortic position who are in sinus rhythm and without left atrial enlargement, therapy with warfarin to a target INR of 2.5 (range, 2.0-3.0) is recommended.
Anticoagulation for prosthetic heart valves: Management of ... - UpToDate
2023年4月20日 · Anticoagulation is required in patients with mechanical heart valves and in selected patients early after bioprosthetic valve implantation or after bioprosthetic valve thrombosis. (See 'Antithrombotic therapy for prosthetic valves' below.)
Apixaban or Warfarin in Patients with an On-X Mechanical Aortic Valve …
2023年5月6日 · Vitamin K antagonists are the only oral anticoagulants approved to prevent valve thrombosis and valve-related thromboembolism in patients with mechanical heart valves. Whether patients with an...
2020 ACC/AHA Guideline for the Management of Patients With …
In patients with a mechanical mitral valve replacement who experience a stroke or systemic embolic event while in therapeutic range on VKA anticoagulation, it is reasonable to increase the INR goal from 3.0 (range, 2.5–3.5) to 4.0 (range, 3.5–4.0) or to add daily low-dose aspirin (75–100 mg), with assessment of bleeding risk.
2024 ACC/AHA Valvular and Structural Heart Disease Measures: …
2024年3月14日 · In patients with a mechanical valve prosthesis, there is high-level evidence that therapy with an oral vitamin K antagonist (VKA) at an appropriate international normalized ratio goal reduces the incidence of valve thrombosis, thromboembolic events, …
Anticoagulation and Antiplatelet Strategies After On-X Mechanical ...
Investigational approaches to reduce the burden of anticoagulation for patients with mechanical heart valves have included targeting a lower international normalized ratio (INR), use of nonwarfarin oral anticoagulants, and dual-antiplatelet therapy (DAPT) for thromboembolic (TE) prophylaxis (4–8).
“Bridging” and Mechanical Heart Valves | Circulation
2006年1月31日 · Measurement of the prothrombin time, which is standardized by reporting the result as the international normalized ratio (INR), assesses the anticoagulant effect of warfarin. For most mechanical heart valves, the target INR ranges between 2.0 and 3.5.
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