2024年2月2日 · Microtubule-Affinity Regulating Kinase 2 (MARK2), a member of the serine/threonine protein kinase family, phosphorylates microtubule-associated proteins,...

Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene. [5][6][7] EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer.

Microtubule-Affinity Regulating Kinase 2 (MARK2), a member of the serine/threonine protein kinase family, phosphorylates microtubule-associated proteins, playing a crucial role in cancer and neurodegenerative diseases. This kinase regulates multiple signaling pathways, including the WNT, PI3K/AKT/mT …

2024年12月2日 · In this study, we used paralog cotargeting CRISPR screens to identify kinases MARK2/3 as absolute catalytic requirements for YAP/TAZ function in diverse carcinoma and sarcoma contexts. Underlying this observation is the direct MARK2/3-dependent phosphorylation of NF2 and YAP/TAZ, which effectively reverses the tumor suppressive activity of the ...

MARK2 and its invertebrate homologue Par1B are kinases that regulate the microtubule cytoskeleton to mediate polarization of neurons in mammals and embryos in invertebrates. However, the role of MARK2 in cancer cell migration is unclear.

2021年3月11日 · Here we report the identification of a direct kinase of eIF2α, microtubule affinity-regulating kinase 2 (MARK2), which phosphorylates eIF2α in response to proteotoxic stress. The activity of MARK2 was confirmed in the cells lacking the 4 previously known eIF2α kinases.

Through a Phos-tag-based kinome-wide screen, we identified MARK2 as a critical regulator for paclitaxel chemosensitivity in PDAC. We show that MARK2 is phosphorylated by CDK1 in response to antitubulin chemotherapeutics and in unperturbed mitosis.

2022年6月20日 · Using a mutant lacking the membrane-binding domain, we found that membrane association is required for focal adhesion targeting of MARK2, where it specifically enhances cell protrusion by promoting FAK phosphorylation and formation of focal adhesions oriented in the direction of migration to mediate directionally persistent cell motility.

这个基因编码Par-1家族丝氨酸/苏氨酸蛋白激酶成员。 该蛋白是上皮细胞和神经细胞细胞极性的重要调节剂，并通过磷酸化和失活几个与微管相关的蛋白质来控制微管的稳定性。 该蛋白定位在细胞膜上。 已发现该基因编码不同异构体的多种转录变异体。 [RefSeq,2009年7月提供] Dir./Indir. Human chromosome 11 DNA sequence and analysis including novel gene identification. Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.

2024年11月19日 · MARK2 is a serine/threonine kinase that plays key roles in cell polarity establishment and microtubule dynamics in various cellular contexts. In brain, MARK2 regulates synaptic connectivity and neuronal excitability (summary by Caiola et al., 2024).