Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.

6 天之前 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Among its related pathways are Prolactin Signaling and Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

2021年9月10日 · MYC activation drives cancer progression through mechanisms involving either the cell-intrinsic acquisition of hallmarks of cancer or dysregulation of the tumour microenvironment and host...

2025年3月27日 · This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX.

2023年10月23日 · MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier that regulates almost every physiological process in a cell including cell cycle, proliferation, metabolism, differentiation, and apoptosis. MYC interacts with several cofactors, chromatin modifiers, and regulators to direct gene expression.

2021年8月9日 · MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels.

2017年8月1日 · MYC gene encodes a multifunctional, nuclear phosphoprotein that controls a variety of cellular functions, including cell cycle, cell growth, apoptosis, cellular metabolism and biosynthesis, adhesion, and mitochondrial biogenesis.

The v-myc avian myelocytomatosis viral oncogene homolog (MYC) gene encodes a nuclear phosphoprotein that functions in cell cycle progression, apoptosis, and cellular transformation. The protein also functions as a transcription factor that controls gene expression.

该基因编码的蛋白质是一种多功能的核磷蛋白，在细胞周期进程、细胞凋亡和细胞转化中发挥作用。 它作为调节特定靶基因转录的转录因子发挥作用。 该基因的突变、过表达、重排和易位与人类的多种造血肿瘤、白血病和淋巴瘤（包括伯基特淋巴瘤）有关。 有证据表明，从上游框内非 AUG (CUG) 和下游 AUG 起始位点开始的替代翻译会导致在人和小鼠中产生具有不同 N 末端的两种亚型。 在压力条件下，例如高细胞密度和甲硫氨酸剥夺，非 AUG 启动蛋白的合成会显着增加，表 …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC triggers selective gene expression amplification to promote cell growth and proliferation.