2025年3月30日 · MST1 (Macrophage Stimulating 1) is a Protein Coding gene. Diseases associated with MST1 include Immunodeficiency 14 and Cholangitis, Primary Sclerosing . Among its related pathways are Hippo-Merlin signaling dysregulation and Signaling by …

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded by the MST1 (macrophage-stimulating 1) gene. [5][6][7] ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. ^ "Mouse PubMed Reference:".

2013年8月28日 · The Hippo signaling pathway has emerged as a critical regulator for organ size control. The serine/threonine protein kinases Mst1 and Mst2, mammalian homologs of the Hippo kinase from Drosophila, play the central roles in the Hippo pathway controlling the cell proliferation, differentiation, and apoptosis during development.

MST1 和 MST2 是巨噬细胞限制细菌感染的关键因素. 鉴于缺乏 MST1 的人类会经历反复感染，作者试图确定缺乏 MST1/2 是否会降低巨噬细胞限制入侵细菌的能力。作者用删除了鞭毛蛋白基因的毒性嗜肺菌菌株Lp02ΔflaA挑战WT和Mst1/2-/-iBMDMs，并测量其胞内复制情况。

由该基因编码的蛋白质包含四个 kringle 结构域和一个丝氨酸蛋白酶结构域，类似于在肝生长因子中发现的蛋白质。 尽管存在丝氨酸蛋白酶结构域，但编码的蛋白质可能没有任何蛋白水解活性。 这种蛋白质的受体是 RON 酪氨酸激酶，它在激活后会刺激肺纤毛上皮细胞的纤毛运动。 这种蛋白质被分泌和切割形成由二硫键桥接的 α 链和 β 链。 [RefSeq 提供，2010 年 1 月] The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to …

MST1是在1995年首次由Creasy和Chernoff两位科学家通过淋巴细胞cDNA文库克隆筛选得到的酵母Ste20的同源蛋白。MST1/STK4属于哺乳动物Ste20激酶GCKⅡ(生发中心激酶)亚家族,由487个氨基酸组成,分子量为55.7 kDa,包含N端激酶结构域和C端调节域,K59位点突变将导致其激酶活性失活 。

2024年12月25日 · mtorc1（哺乳动物雷帕霉素靶蛋白复合物1）是一种调控细胞生长和代谢的关键分子。stat1（信号转导和转录激活因子1）则是一种参与免疫应答和细胞增殖调控的转录因子。在ccl2缺失的情况下，mst1-mtorc1-stat1轴的磷酸化水平上调，这导致了bcr信号传导的增强。

2025年1月4日 · Title: Mst1 promotes mitochondrial dysfunction and apoptosis in oxidative stress-induced rheumatoid arthritis synoviocytes. Macrophage stimulating 1-induced inflammation response promotes aortic aneurysm formation through triggering endothelial cells death and activating the NF-kappaB signaling pathway.

Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury.

Mammalian sterile 20-like kinase 1 (MST1) is a protein kinase, and the occurrence of many heart diseases is related to the continuous activation of the MST1 gene. With the deepening of the research, the potential role of MST1 in promoting the development of …