肿瘤免疫治疗----先了解下MSI-H/dMMR - 知乎 - 知乎专栏
如果任一蛋白丢失(表达阴性)即认为是dmmr(即msi-h)，如果四个基因全部阳性表达即认为是pmmr(即mss或msi-l)。 免疫组化检测简单易行，各个医院都能做，费用较低， 目前是医院主 …
60秒dMMR/MSI-H实体瘤简明释义 - 知乎 - 知乎专栏
微卫星不稳定 （microsatellite instability, MSI）最早发现于结直肠癌，目前已知在子宫内膜癌、胃癌、小肠、肝胆系统和结直肠癌等多种相关实体瘤中均涉及 错配修复蛋白 缺失（deficient …
Epidemiology, pathogenesis, biology and evolving management of MSI …
4 天之前 · Deficiency in DNA mismatch repair (dMMR) is a common pathway of carcinogenesis across different tumour types and confers a characteristic microsatellite instability-high (MSI …
Understanding MSI-High and DNA Mismatch Repair (dMMR)
2020年2月8日 · Microsatellite instability (MSI) is the condition of genetic hypermutability or a predisposition to mutations in cells that results from the bodies impaired DNA mismatch repair …
再谈MMR与MSI - 知乎 - 知乎专栏
mmr与msi检测不一致情况主要有以下两种类型： ♦ dmmr vs mss，其发生的原因可能为： ①某些mmr蛋白的缺失，被功能代偿. ②mlh1启动子甲基化导致的肿瘤异质性，从而影响结果判断。 …
Microsatellite instability: a review of what the oncologist should …
2020年1月13日 · The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR) tumors recently have been reported that can benefit from immunotherapy, and MSI …
Microsatellite Instability - Defective DNA Mismatch Repair - ESMO
There are two clinically useful tests to detect a dMMR in cancer (see images below): i) identification of MSI by molecular testing of poly-A microsatellites, which represents direct …
ESMO recommendations on microsatellite instability testing for ...
MSI/dMMR can be identified using immunohistochemistry to detect loss of MMR proteins and/or molecular tests to show microsatellite alterations. Together with tumour mutational burden …
The Role of MSI Testing Methodology and Its Heterogeneity in
2 天之前 · MSI is a crucial biomarker for selecting CRC patients for immunotherapy. Here, we analyze the first results from the observational prospective trial BLOOMSI (NCT06414304), …
一文读懂：为你详细解读微卫星不稳定 - 丁香园
2019年5月16日 · 2017 年，FDA 批准 K 药用于「MSI-H/dMMR」实体瘤治疗，K 药也成为首个「不看部位看 marker」的抗肿瘤免疫药物。 我们就来了解一下什么是 MSI/MMR，以及哪些患 …