2010年11月19日 · We also demonstrate that MSC IDO activity induce the differentiation of monocytes into IL-10 secreting M2 immunosuppressive macrophages (CD14 + /CD206 +). …

2024年11月26日 · Our research reveals IL-10RA as a pharmacological target in stromal cells for enhancing T cell-mediated PDAC eradication by downregulating IDO via blocked IL-10/IL …

These IDO-expressing mouse MSC transfectants (MSC-IDO) provide a unique opportunity to study the role of human IDO without interference from iNOS. Since MSCs have been shown to …

2009年5月29日 · Splenocytes stimulated with alloantigen in the presence of the MSC culture supernatant (CS) produced a significant amount of IL-10, which was attributed to an increase …

2023年9月23日 · Finally, transplanted CXCL11-IL10-MSCs increased CD19+ and CD4+ lymphoid cells, and decreased CD11b+ Ly6g myeloid cells in an ALI mouse model. These results …

2021年4月9日 · Based on data from this study, we would suggest immortalized MSC-derived EVs enriched with IDO1 as an appropriate candidate in the modulation of immune-related …

2017年6月23日 · Interleukin (IL)-10 is a contributing factor to neuroprotection of mesenchymal stem cell (MSC) transplantation after ischemic stroke. Our aim was to increase therapeutic …

2014年3月1日 · We found that MSC-IDO dramatically reduced both tumor-infiltrating CD8(+) T cells and B cells. Our findings offer an important new line of evidence that interventional …

In summary, this study suggests that MSCs can control EAE via IDO pathway to promote the proportion and function of CD5+ IL-10+ B cells, providing a promise to treat patients with MS …

2010年11月19日 · We also demonstrate that MSC IDO activity induce the differentiation of monocytes into IL-10 secreting M2 immunosuppressive macrophages (CD14+/CD206+). More …