Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-β1/p38 MAPK …
2023年3月13日 · In this study, we demonstrated that circ-Ntrk2 expression is upregulated in hypoxic lung tissues and PASMCs and that its deficiency could improve pulmonary vascular …
Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of …
2013年11月15日 · Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, …
A Novel p38 Mitogen-activated Protein Kinase/Elk-1 Transcription …
In this study, we included immunocyto- and -histochemical evidence of p38 MAPK activation in human PAH specimens: EC PAH, cells that retain the PAH phenotype in culture, and lung …
Pulmonary artery smooth muscle cell phenotypic switching: A key …
2023年5月1日 · Classic protein kinase pathways inhibit the dedifferentiation and proliferation of PASMCs by mediating the mitogen-activated protein kinase (MAPK), Janus kinase …
Cellular mechanosignaling in pulmonary arterial hypertension
We developed a computational model of PAAFs mechanosignaling that included TGFβ, MAPK, PDGF, tumor necrosis factor α (TNFα), hypoxia, fibroblast growth factor (FGF), angiotensin II, …
CXCR7 promotes pulmonary vascular remodeling via targeting …
2024年4月4日 · CXCR7 expression was upregulated in PAH with activation of MMP2, and inhibition of CXCR7 ameliorated the development of PAH. Our purpose was to determine the …
Airborne PAHs inhibit gap junctional intercellular communication …
Fluoranthene, 1- and 9-methylanthracene induced strong and sustained activation of MAPK ERK1/2, whereas MAPK p38 was activated rather nonspecifically by all tested PAHs. …
Is p38 MAPK a Dark Force in Right Ventricular Hypertrophy and Failure ...
In the systemic vasculature, p38 mitogen-activated protein kinase (MAPK) is part of an important inflammatory pathway. In the pulmonary vasculature, p38 MAPK is a new area of investigation …
Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of …
2013年11月15日 · Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, …
Hyperplastic Growth of Pulmonary Artery Smooth Muscle Cells …
2015年4月23日 · In the PAH cells PDGF-BB and FGF2 augment the dysregulated cell proliferation, also through mTOR/6SK. Additionally, blocking the activation of mTOR also …