2024年12月16日 · Depletion of HSP27 or the inhibition of HSP27 phosphorylation alters the dynamics of p62 condensates on stressed lysosomes, significantly inhibiting p62-dependent lysophagy. Thus, we define a novel lysosomal quality control mechanism in which lysosomal injury triggers a p38 MAPK/MK2 signaling cascade promoting p62-dependent lysophagy.

2017年11月24日 · ER stressors lead to a PERK-dependent activation and recruitment of MKK4 to lysosomes, activating p38 MAPK at lysosomes. Lysosomal p38 MAPK directly phosphorylates the CMA receptor LAMP2A...

2017年10月4日 · This study demonstrates for the first time that EGF can stimulate lysosome trafficking to the cell periphery and that EGF-induced lysosome trafficking is necessary for protease secretion and tumor cell invasion medicated in part through p38 MAPK activation.

2023年7月28日 · Enhancing p38 signaling with caspase cleavage-resistant PMK-1 protects lysosomal and neuronal integrity extending a youthful phase. PMK-1 works through a complex transcriptional program to...

丝裂原活化蛋白激酶（mapk）级联是调节细胞多种生理过程的关键信号通路，包括增殖、分化、凋亡和应激反应。 在真核细胞中已经确定了以下四条MAPK级联途径：ERK、JNK、p38 MAPK和ERK5信号转导途径。

2011年6月1日 · Extracellular signal-regulated kinase (ERK) is a mitogen-activated protein kinase (MAPK) that functions as the major effector of the Ras oncoprotein. MAPK pathways consist of an initial GTPase-regulated kinase (MAPKKK) that phosphorylates and activates an intermediate kinase (MAPKK) that, in turn, phosphorylates and activates an effector kinase ...

2024年12月16日 · Gallagher et al. demonstrate that HSP27 is phosphorylated by a p38 MAPK/MK2 signaling cascade upon lysosomal stress. Phospho-HSP27 is specifically recruited to damaged lysosomes via a direct interaction with SQSTM1/p62 and modulates the material properties of p62 biomolecular condensates to promote efficient lysophagy.

2023年8月4日 · The key mechanisms of lysosome-mediated mucolipin-1(Mcoln1) and mitogen-activated protein kinase (MAPK) activation in M2 macrophage polarization have been unveiled. RNA sequencing (RNA-seq) was used to further explore the key mechanism underlying high-mobility group box 1(HMGB1)-mediated Cathepsin L(CTSL)-lysosome function blockade.

2024年12月16日 · Depletion of HSP27 or the inhibition of HSP27 phosphorylation alters the dynamics of p62 condensates on stressed lysosomes, significantly inhibiting p62-dependent lysophagy. Thus, we define a novel lysosomal quality control mechanism in which lysosomal injury triggers a p38 MAPK/MK2 signaling cascade promoting p62-dependent lysophagy.

Activated mTORC1 orchestrates various cellular functions, for example, macromolecule biosynthesis, energy metabolism, autophagy, cell growth, responses to growth factors, and the trafficking and maturation of lysosomes. The Ragulator can also regulate a branch of the MAPK pathway by recruiting MEK1 to MP1/LAMTOR3.