Laron syndrome (LS), also known as growth hormone insensitivity or growth hormone receptor deficiency (GHRD), is an autosomal recessive disorder characterized by a lack of insulin-like growth factor 1 (IGF-1; somatomedin-C) production in response to growth hormone (GH; hGH; somatotropin). [6]

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Laron syndrome is a rare form of short stature that results from the body's inability to use growth hormone , a substance produced by the brain's pituitary gland that helps promote growth. Explore symptoms, inheritance, genetics of this condition.

Laron syndrome is a condition that occurs when the body is unable to utilize growth hormone. It is primarily characterized by short stature. Other signs and symptoms vary but may include reduced muscle strength and endurance; hypoglycemia in infancy; delayed puberty; short limbs (arms and legs); and obesity.

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Laron’s syndrome (LS) is a rare genetic disorder characterized by insensitivity to growth hormone (GH). Up to the present time, over 70 mutations of GH receptor (GHR) gene have been identified leading to GH/insulin-like growth factor type 1 (IGF1) signaling pathway defect.

Primary growth hormone resistance or growth hormone insensitivity syndrome, also known as Laron syndrome, is a hereditary disease caused by deletions or different types of mutations in the growth hormone receptor gene or by post-receptor defects. ...

Jul 29, 2022 · Laron syndrome, also known as Laron-type dwarfism, is a rare genetic disorder in which there is a deficit of response to growth hormones. People with Laron syndrome have short stature and other physical features, caused by mutations in the growth hormone receptor gene.

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A number sign (#) is used with this entry because of evidence that Laron syndrome, also known as growth hormone insensitivity syndrome, is caused by homozygous or compound heterozygous mutation in the growth hormone receptor gene (GHR; 600946) on chromosome 5p.