Negative regulation of NF-κB p65 activity by serine 536 ... - Science
2016年8月23日 · Ser 536 (S536) of the p65 subunit represents the site with the most potent inducible phosphorylation in response to inflammatory stimuli (9), and it is highly conserved …
Negative regulation of NF-κB p65 activity by serine 536 ... - PubMed
2016年8月23日 · We investigated the contribution of the phosphorylation of the NF-κB subunit p65 at the IKK phosphorylation site serine 536 (Ser(536)) in humans, which is thought to be …
IKKβ Plays an Essential Role in the Phosphorylation of RelA/p65 on ...
2003年6月1日 · Using IKKα −/− and IKKβ −/− mouse embryonic fibroblasts (MEFs), we found that IKKβ was essential for the LPS-induced p65 phosphorylation on serine 536, whereas loss of …
Phosphorylation of Serine 536 of p65(RelA) Downregulates
2024年9月8日 · Recently, a novel transcriptional regulatory mechanism of NF-κB involving the phosphorylation of serine 536 (534 in mice; S534) of its p65 subunit was reported; however, …
Transient and Selective NF-κB p65 Serine 536 Phosphorylation …
2004年5月15日 · Phosphorylation of serine 536 contributes to NF-κB trans activation, and mutation of this serine to alanine impairs LPS- or LTβ-induced stimulation of NF-κB p65 trans …
Phosphorylation of Serine 536 of p65(RelA) Downregulates
2024年9月8日 · Nuclear factor-κB (NF-κB) is a transcription factor that regulates the expression of various genes involved in inflammatory diseases and immune responses. Recently, a novel …
IKK beta plays an essential role in the phosphorylation of
2003年6月1日 · Using mouse embryonic fibroblasts lacking either IKK alpha or IKK beta, we found that IKK beta played an essential role in LPS-induced p65 phosphorylation on serine …
Bruton's Tyrosine Kinase Is Involved in p65-mediated …
2005年6月24日 · LPS induced a strong increase in p65 phosphorylation on serine 536 in multiple cell types tested, including HEK293-TLR4 and U373 cells (Fig. 3a, left-and right-hand panels, …
Ser536 (S536) of the p65 subunit represents the site with the most potent inducible phosphorylation in response to inflammatory stimuli (9), and it is highly con-served among …
Specification of the NF-κB transcriptional response by p65 ...
2010年5月27日 · High-resolution microscopy and surface rendering revealed serine 536 phosphorylated p65 predominantly in the cytosol, while serine 468 phosphorylated p65 mainly …