An examination of the LPS-TLR4 immune response through the …
2025年3月18日 · The LPS-TLR4 immune response is a critical mechanism in the body's defense against Gram-negative bacterial infections, yet its dysregulation can lead to severe …
LPS/TLR4 signal transduction pathway - PubMed
The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. …
Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver ...
2021年1月25日 · In summary, these results demonstrate that silencing of TLR4 attenuates LPS-induced liver injury through inhibition of inflammation and apoptosis via TLR4/MyD88/NF-κB …
Recognition of lipopolysaccharide pattern by TLR4 complexes
2013年12月6日 · The common structural pattern of LPS in diverse bacterial species is recognized by a cascade of LPS receptors and accessory proteins, LPS binding protein (LBP), CD14 and …
The Immunobiology of TLR4 Agonists: From Endotoxin Tolerance …
TLR4 agonists facilitate T cell clonal expansion and activation by augmenting cytokine production and antigen presentation. The augmentation of Th1 polarity and activation facilitates B cell …
The effect of lysophosphatidic acid on Toll-like receptor 4 ... - PubMed
In this study, we investigated the effects of LPA on TLR4 expression, nuclear translocation of NF-κB p65 subunit, and changes in the cytokine tumor necrosis factor α (TNF-α) in human THP-1 …
TLR4——细菌LPS的受体 - 知乎 - 知乎专栏
Toll 样受体 4 （Toll-like receptor 4，TLR4）是由 Poltorak 等于 1998 年发现的 一种 I 型跨膜蛋白，其由 TLR4 基因编码，并表达于包括单核细胞，巨嗜细胞在内 的多种组织细胞中，可以识 …
Lipopolysaccharide Recognition in the Crossroads of TLR4 and …
Here we describe the LPS-induced TLR4 and caspase-4/11 mediated signaling pathways and their cross-talk and scrutinize specific structural features of the lipid A motif of diverse LPS …
Lysophosphatidic Acid Promotes Expression and Activation of …
Lysophosphatidic acid (LPA) is an active compound of oxidized low-density lipoprotein that serves as an endogenous TLR4 ligand. Ligand activation of TLR4 activates nuclear factor-kappaB …
The effect of lysophosphatidic acid on Toll-like receptor 4
2016年9月13日 · In this study, we investigated the effects of LPA on TLR4 expression, nuclear translocation of NF-κB p65 subunit, and changes in the cytokine tumor necrosis factor α (TNF …