LNCaP cells are a cell line of human cells commonly used in the field of oncology. LNCaP cells are androgen -sensitive human prostate adenocarcinoma cells derived from the left supraclavicular lymph node metastasis from a 50-year-old caucasian male in 1977.

LNCaP clone FGC is a cell line exhibiting epithelial morphology that was isolated in 1977 by J.S. Horoszewicz, et al., from a needle aspiration biopsy of the left supraclavicular lymph node of a 50-year-old, White, male (blood type B+) with confirmed diagnosis of metastatic prostate carcinoma.

May 3, 2022 · The classic and most widely used human prostate cancer cell lines are DU145, PC3, and LNCaP cells (2); among these, only LNCaP cells express AR and are androgen responsive. This feature is undoubtedly related to why LNCaP cells have a unique capacity to model prostate cancer progression.

LNCaP (Lymph Node Carcinoma of the Prostate) is a commonly used human cell line in the cancer research field. These cells are extensively applied to study the biology of prostate cancer and to evaluate potential treatments.

Feb 14, 2023 · The LNCaP cell line is the most widely used in vitro prostate cancer model and was established in 1980 to fulfil the need of an AR-positive cell line.

LNCaP cells are epithelial cells with weakly-adherent qualities. They grow well in vitro, albeit slowly, and can be grown in aggregates or as individual cells. The cells attach lightly to the …

The LNCaP cell line was established from a metastatic lesion of human prostatic adenocarcinoma. The LNCaP cells grow readily in vitro (up to 8 x 10 (5) cells/sq cm; doubling time, 60 hr), form clones in semisolid media, are highly resistant to human fibroblast interferon, and show an aneuploid (modal …

May 3, 2022 · Among the relatively few established human prostate cancer cell lines, LNCaP cells are unique in their ability to model key stages of prostate cancer progression. Analyses of LNCaP cells and their derivatives have been invaluable for elucidating important translational aspects of prostate tumorigene …

LNCaP cells express the clinical marker for prostate cancer, prostate-specific antigen (PSA), which is an androgen-regulated gene. The abilities of LNCaP cells to be grown in vivo as xenografts, progress to the castration-resistant stage, and secrete PSA mimics several important aspects of clinical disease.

LNCaP cells are epithelial cells with adherent (and semi-adherent) qualities when growing in cell culture. The LNCaP cell line is sensitive to the hormones estrogen and androgen, which can …