Targeting LDH has emerged as a vital approach in drug discovery, leading to the identification of LDH inhibitors among natural compounds, such as polyphenols, alkaloids, and terpenoids. …

Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid)是一种 lactate dehydrogenase (LDH) 的抑制剂，可特异性地抑制LDH‑A。 Sodium oxamate (SO) 通过下调 CDK1/cyclin B1 途径诱 …

GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC 50 s of 2.6 and 43 nM for hLDHA and hLDHB, respectively. IC 50 & Target IC50: 2.6 nM (hLDHA), 43 …

2021年11月1日 · Here, we developed a high-throughput mass spectrometry screening system using an LDHB enzyme assay by detecting NADH and NAD +. As a result, we identified a …

2019年3月18日 · Manerba et al. identified galloflavin (GF) as novel inhibitor for lactate dehydrogenase. According to their result, galloflavin arrest aerobic glycolysis through binding …

FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a K i of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production …

Targeting LDH not only inhibits the proliferation, tumorigenesis, and progression, but also suppresses the invasion, metastasis, and angiogenesis of cancer (Feng et al., 2018). …

Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and …

2019年3月8日 · In this study, among various selenobenzenes that we tested, we found that 1- (phenylseleno)-4- (trifluoromethyl)benzene (PSTMB) has the most potent inhibitory effect on …

Research has focused mainly on the selection of modulator especially as far as LDH isozymes (especially LDH-5) and lactate dehydrogenases of Plasmodium falciparum (pfLDH) are …