Neoantigen sequestrated autophagosomes as therapeutic cancer …
2024年12月1日 · Increased proportions of IFN-γ- and TNF-α-positive CD4 + T cells and CD8 + T cells in tumors were also detected in mice treated with LC3/Mut plus anti-PD-1 (Fig. 5 e-h and …
Allele-selective lowering of mutant HTT protein by HTT–LC3 linker ...
2019年10月30日 · We hypothesized that compounds that interact with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3) 1 and the disease-causing …
LC3蛋白：细胞自噬中的关键执行者 - 知乎 - 知乎专栏
LC3蛋白（也称为 Microtubule-associated protein 1 light chain 3）是一种与细胞自噬相关的蛋白质，在细胞自噬的过程中发挥重要的作用。 通过检测LC3蛋白的表达水平和形态变化，可以研究 …
自噬标志物—LC3检测要点 - 知乎 - 知乎专栏
在哺乳动物中，存在 4 种LC3异构体（LC3A、 LC3B 、 LC3B2和 LC3C），在不同的组织细胞中表达会有差异。 目前主要研究的是LC3A和LC3B，LC3C在许多细胞中表达量很低，研究的也 …
ninjasource/lc3-codec: Low Complexity Communication Codec - GitHub
Low Complexity Communication Codec. This is an implementation of the the Bluetooth (r) LC3 Audio Codec revision 1.0 (released on 2020-09-15) targeting no_std environments. This is not …
Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions
2024年5月17日 · Methylmalonic acidemia (MMA) is a rare inborn error of propionate metabolism caused by deficiency of the mitochondrial methylmalonyl-CoA mutase (MUT) enzyme. As …
Lithium chloride (LiCl) induced autophagy and ... - ScienceDirect
2018年8月1日 · This study evaluated whether lithium chloride (LiCl) prevents cytoplasmic accumulation of mutant-transforming growth factor β-induced protein (Mut-TGFBI) in granular …
Inhibition of Lonp1 induces mitochondrial remodeling and …
2023年1月1日 · Mechanistically, Lonp1 knockdown decreases area of mitochondrial networks and induces mitochondrial depolarization. Furthermore, Lonp1 inhibition reduces the level of LC3 …
肥胖病研究新火花：m6A甲基化可调控自噬和脂肪形成 - 上海英拜 …
异位表达fto-wt，但不是fto-mut，显着增加lc3-ii：i表达，lc3斑点显着增强,自噬体的数量提高。 这些结果证明FTO去甲基化的活性是前脂肪细胞中自噬所必需的。
A novel autoregulatory loop between the Gcn2-Atf4 pathway and
2015年4月10日 · We first analysed the intracellular distribution of the microtubule-associated protein light chain 3 (LC3), which shifts from diffuse to punctate during autophagosome …