从PRF的提出到其衍生物纯富血小板纤维蛋白（pure platelet-rich fibrin，P-PRF）、富白细胞血小板纤维蛋白（leukocyte- and platelet-rich fibrin，L-PRF）、改良型富血小板纤维蛋白（advanced platelet-rich fibrin，A-PRF）与可注射型富血小板纤维蛋白（injectable platelet-rich fibrin，i-PRF ...

Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a derivative of PRP where autologous platelets and leukocytes are present in a complex fibrin matrix [1][2] to accelerate the healing of soft and hard tissue [3] and is used as a tissue-engineering scaffold in oral and maxillofacial surgeries.

2024年5月27日 · Autologous platelet concentrates (APCs) have demonstrated clear benefits across various clinical applications, including alveolar ridge preservation, guided tissue regeneration, guided bone regeneration, sinus floor elevation (both lateral window approach and transcrestal technique), endodontic surgery, the treatment of medication-related osteon...

2020年2月12日 · This study evaluates the use of L-PRF as an autologous scaffold in nerve regeneration, and Schwann cells (SCs) proliferation and secretion of neurotrophic factors and its anti-inflammatory effect...

2018年11月5日 · Leukocyte and platelet-rich fibrin (L-PRF) is a 3-D autogenous biomaterial derived via simple and rapid centrifugation of whole blood patient samples, in the absence of anti-coagulants, bovine thrombin, additives or any gelifying agents.

In recent years, leucocyte- and platelet-rich fibrin (L-PRF) has emerged as a highly promising technique with many applications in periodontal therapy. It is being used successfully to repair periodontal bony defects, for ridge preservation, for sinus-floor elevation, and in implant surgery.

Platelet-rich fibrin (PRF) represents second generation of platelet concentrates, which has gained increasing awareness in recent years for regenerative procedures. This biologic additive is completely autologous, easy to prepare, has minimal ...

2024年9月4日 · Leukocyte- and platelet-rich fibrin (L-PRF) is an autologous platelet concentrate, prepared by centrifugation of blood and consisting of a dense fibrin network with incorporated leukocytes and platelets. This study aims to perform an in-depth analysis of the cells, growth factors, and transcriptome of L-PRF.

The new generation of platelet-rich fibrin (PRF), namely advanced PRF (A-PRF), has different biological and mechanical properties compared to those of leukocyte-PRF (L-PRF).

Objective: To determine whether leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF+) differ in their in vitro capacity to induce proliferation and migration of periodontal fibroblasts. Background: L-PRF and A-PRF + are autologous materials used in periodontal regenerative surgery.