Targeting glutaminase 1 (GLS1) by small molecules for anticancer ...
2023年4月5日 · The GLS1 gene gives rise to two splicing variants, kidney glutaminase (KGA) and glutaminase C (GAC), with a shared N-terminal sequence (1–550) but distinct C-terminal …
Structural basis for activation and filamentation of glutaminase
2023年10月13日 · Glutaminase catalyzes the first step of glutamine metabolism, converting glutamine to glutamate, which enters the tricarboxylic acid cycle. In human, glutaminase is …
Filament formation drives catalysis by glutaminase enzymes
2024年3月4日 · Gls encodes kidney-type glutaminase (KGA) and its C-terminal truncated splice variant glutaminase C (GAC) which is highly expressed in many cancers. Gls 2 encodes only …
生命学院刘冀珑课题组解析谷氨酰胺酶代谢纤维激活机制
2023年10月16日 · GLS1可翻译产生两种不同的活性形式：肾谷氨酰胺酶A（KGA）和高度活化的谷氨酰胺酶亚型C（GAC），其中GAC亚型在多种癌症中因其对谷氨酰胺的高度利用而高度表 …
KGA and GAC are enhanced in cancer, but only GAC is found in ...
Isozymespecific antibodies show that protein levels of both GAC and KGA increase in tumor tissues when compared to their normal healthy counterparts, and correlate both with the …
A glutaminase isoform switch drives therapeutic resistance and …
2021年3月22日 · Our results suggest that eventually the tumor cells switch GLS1 expression from the AR-dependent KGA isoform to the androgen-independent and enzymatically more potent …
Structural Basis for the Active Site Inhibition Mechanism of …
2014年1月23日 · Here we report the active site inhibition mechanism of KGA through the crystal structure of the catalytic domain of KGA (cKGA) in complex with 6-diazo-5-oxo-L-norleucine …
Recent insights into the roles and therapeutic potentials of GLS1 in ...
2025年4月2日 · In the KGA complex, the trifluoromethoxy group does not form any hydrogen bonds with KGA, but in the GAC complex, the fluorine atoms can form hydrogen bonds with …
Upregulation of GLS1 Isoforms KGA and GAC Facilitates …
Our data demonstrate increased expression of GLS1 isoforms KGA and GAC with mitochondrial localization in latently EBV-infected cells and de novo EBV-infected PBMCs. c-Myc …
郑州大学吴缅/张莉蓉/邵凤民揭示肿瘤顽强生命力的潜在机制_经济 …
2021年3月29日 · 谷胱甘肽是一种三肽（Glu-Cys-Gly），可通过谷氨酸脱氢酶1（GLUD1）产生NADPH来中和过氧化物自由基并介导ROS（活性氧）稳态。 线粒体谷氨酰胺酶（GA）催化 …